The likes of Tottenham, Liverpool, Chelsea, West Ham and Leicester are all still fighting in four fronts both domestically and in Europe.
And many of those clubs will need to count on every member of their squads in what is a season-defining period in mid-December.
Comparatively, the two Manchester outfits have both already had their fixture list trimmed by their early exit from the Carabao Cup.
Arsenal, meanwhile, will enjoy their lightest festive period in years with the Gunners having no European football this term for the first time in 25 years.
But on the opposite end of the fixture table, which Premier League team will be working extra hard this Christmas? talkSPORT.com takes a look…
Arsenal
Mikel Arteta's side will be in action nine times across the course of festive period.
Arsenal start with a difficult away day to Old Trafford to take on Manchester United which precedes a run of seven games before they finish at home to Man City on January 1, 2022.
The Gunners lack of European football does ease their fixture list slightly but they do have to squeeze in a League Cup quarter final against Sunderland as well.
That game comes in the middle of Arsenal's busiest period in which they have to play six times in 18 days - an average of playing a match every three days!
Man United (a) December 2
Everton (a) December 6
Southampton (h) December 11
West Ham (h) December 15
Leeds (a) December 18
Sunderland (h) December 21
Norwich City (a) December 26
Wolves (h) December 28
Man City (h) January 1
Aston Villa
The Villains play one less than Arsenal over the same period with their third-round Carabao Cup defeat to Chelsea clearing their schedule of that extra game.
But Villa have an extremely tough run of games in which they play Man City, Leicester, Liverpool and Chelsea in a matter of weeks.
The one consolation for the clubs is the amount of rest Villa will be afforded between matches compared to the rest of the Premier League.
The Birmingham outfit have four days between most of their December games with a two-day turnaround after Boxing Day their only physical challenge.
Man City (h) December 1
Leicester City (h) December 5
Liverpool (a) December 11
Norwich (a) December 14
Burnley (h) December 18
Chelsea (h) December 26
Leeds (a) December 28
Brentford (a) January 2
Brentford
As was the case with Arsenal, Thomas Frank's side will be in action nine times across the course of festive period.
But unlike the Gunners, Brentford's fixtures have ensured that the club will have an average of four days rest between most of their games.
The Bees never have less than three days from one match to another but like Aston Villa have a difficult run in December.
Brentford have Premier League ties against Tottenham, Man United and Man City alongside a Carabao Cup clash with Chelsea.
Tottenham (a) December 2
Leeds (a) December 5
Watford (h) December 10
Man United (h) December 14
Southampton (a) December 18
Chelsea (h) December 22
Brighton (a) December 26
Man City (h) December 29
Aston Villa (h) January 2
Brighton
Graham Potter's side are among the teams with the lightest December schedule with eight games over the festive period.
Brighton start December away at West Ham before a trip to Southampton three days later precedes an eight-day rest.
The Seagulls fixtures do increase on December 12 when they host Spurs, three days before welcoming Wolves and then away at United three days after that.
West Ham (a) December 1
Southampton (a) December 4
Tottenham (h) December 12
Wolves (h) December 15
Man United (a) December 18
Brentford (h) December 26
Chelsea (a) December 29
Everton (a) January 2
Burnley
Sean Dyche's men will also enjoy the absence of League Cup duty with eight fixtures affording them at least three days rest between games.
Burnley also have rather favourable games during December, as they face struggling Newcastle, Aston Villa and Watford.
However, the Lancashire outfit do have an intriguing Boxing Day clash with Everton before a trip to Old Trafford a helpful four days later.
Wolves (a) December 1
Newcastle (a) December 4
West Ham (h) December 12
Watford (h) December 15
Aston Villa (a) December 18
Everton (h) December 26
Man United (a) December 30
Leeds (a) January 2
Chelsea
The Blues have been swamped with a hectic Christmas period with TEN matches in just one month - including a clash with title rivals Liverpool.
Thomas Tuchel's men are currently top of the table but face a battle to hold onto their lead with three away games kicking off a busy December.
Chelsea also have to navigate a 2,600-mile return trip to Russia for a Champions League tie with Zenit St Petersburg and a Carabao Cup quarter-final.
Watford (a) December 1
West Ham (a) December 4
Zenit (a) December 8
Leeds (h) December 11
Everton (h) December 16
Wolves (a) December 19
Brentford (a) December 22
Aston Villa (a) December 26
Brighton (h) December 20
Liverpool (h) January 2
Crystal Palace
Patrick Vieira's first time navigating the Christmas period as a manager is much kinder than his old club Arsenal or London rivals Chelsea.
The Frenchman will only oversee seven matches into the New Year however his Palace side will have less rest between games.
The Eagles have a week's rest after opening December away at Man United before three days only separate clashes with Everton, Southampton and Watford.
The Selhurst Park outfit are also in action just two days after a Boxing Day fixture with Spurs as they host Norwich City.
Manchester United (a) December 5
Everton (h) December 12
Southampton (h) December 15
Watford (a) December 18
Tottenham (a) December 26
Norwich City (h) December 28
West Ham (h) January 1
Everton
The Toffees have the standard eight games to play in December but Rafael Benitez will welcome the rest afforded his side between games.
Everton never have less than three days break following a match with certain fixtures even giving them five and six days off at a time.
The added rest will be needed at Goodison Park considering their horror run that includes facing Liverpool, Arsenal, Chelsea and Leicester City.
Liverpool (h) December 1
Arsenal (h) December 6
Crystal Palace (a) December 12
Chelsea (a) December 16
Leicester City (h) December 19
Burnley (a) December 26
Newcastle (h) December 30
Brighton (h) January 2
Leeds
Marcelo Bielsa's men are in for some holiday cheer with only seven games to worry about over the festive fixtures.
However unfortunately for them, those matches involve facing Chelsea, Man City and Liverpool in successive away clashes while also hosting Arsenal.
Leeds will need to ensure they utilise all six days rest before that period that follows the opening December contest against Brentford.
Brentford (h) December 5
Chelsea (a) December 11
Man City (a) December 14
Arsenal (h) December 18
Liverpool (a) December 26
Aston Villa (h) December 28
Burnley (h) January 2
Leicester City
The Foxes are among the clubs with a more congested fixture list, having to play ten matches in a month because of their Europa League exploits.
Brendan Rodgers' men have to travel to Italy for a must-win game against Napoli while also facing Liverpool in a Carabo Cup quarter-final.
Leicester also face the Reds six days later in Premier League action - which comes just two days after a trip to the Etihad to take on champions Man City.
Leicester will play six games in just 17 days around Christmas - the most congested fixture list in the league alongside Tottenham.
Southampton (a) December 1
Aston Villa (a) December 5
Napoli (a) December 9
Newcastle (h) December 12
Tottenham (h) December 16
Everton (a) December 19
Liverpool (a) December 22
Man City (a) December 26
Liverpool (h) December 28
Norwich City (h) January 1
Liverpool
Jurgen Klopp famously doesn't like England's crowded Christmas period - and this year the German won't be happy with his side playing ten times.
The one boost is the Reds have already topped their Champions League group so can afford to rest a few key stars for an away trip to face AC Milan.
Yet after that, Liverpool play four matches in 11 days with three Premier League games and a Carabao Cup quarter-final to navigate.
Everton (a) December 1
Wolves (a) December 4
AC Milan (a) December 7
Aston Villa (h) December 11
Newcastle (h) December 16
Tottenham (a) December 19
Leicester City (h) December 22
Leeds (h) December 26
Leicester City (a) December 28
Chelsea (a) January 2
Manchester City
Pep Guardiola will have his lightest festive period since arriving in England, with his side out of the Carabao Cup for the first time in five seasons.
City do still have nine games in December with a difficult Champions League trip to face RB Leipzig in between a run of much kinder Premier League games.
The Etihad outfit have favourable away-day clashes with top-flight strugglers Aston Villa, Watford and Newcastle.
Aston Villa (a) December 1
Watford (a) December 4
RB Leipzig (a) December 7
Wolves (h) December 11
Leeds (h) December 14
Newcastle (a) December 19
Leicester City (h) December 26
Brentford (a) December 29
Arsenal (a) January 1
Manchester United
The Red Devils do have nine games to manage heading into the New Year, however later fixtures should serve them well.
United are involved in the only match not taking place on Boxing Day while they also have to wait until January 3 to kick-start the action in 2022.
United's biggest tests are both at Old Trafford as well, with an opening December clash with Arsenal preceding a Champions League tie against Young Boys.
Arsenal (h) December 2
Crystal Palace (h) December 5
Young Boys (h) December 8
Norwich City (a) December 11
Brentford (a) December 14
Brighton (h) December 18
Newcastle (a) December 27
Burnley (h) December 30
Wolves (h) January 3
Newcastle
The Magpies' Christmas run of games will go a long way into deciding whether the club will be in the Championship next season.