Both Julen Lopetegui and Gary O'Neil are allegedly on the brink of being removed from their respective positions in the dugout, consequently leading to this game being dubbed 'El Sackico'.
In the case of Wolves, O'Neil has decided to make three changes to the team that succumbed to a 4-0 defeat at the hands of Everton on Wednesday.
While Semedo has returned to the defence after serving a one-match ban, the Portugal international will seemingly feature in a back three alongside Santiago Bueno and Toti Gomes.
Matt Doherty has retained his position on the right, albeit at right wing-back, while goalkeeper Sam Johnstone has been recalled between the sticks in place of Jose Sa.
O'Neil has seemingly decided to go with a 5-3-2 formation, with Craig Dawson and Goncalo Guedes the other two players to drop out of the team.
Meanwhile, Lopetegui - who is facing his former club for the first time since his August 2023 exit - has made two alterations to the team that lost 3-1 at Leicester City last week.
Michail Antonio would have been in contention to start ahead of Danny Ings, but the club legend is now sidelined in the long term after being involved in a car crash at the weekend.
Instead, Crysencio Summerville has been recalled to the attack with Jarrod Bowen moving inside to take the spot of Ings.
Emerson Palmieri also returns at left-back, with Aaron Wan-Bissaka moving to the right and Vladimir Coufal dropping down to the substitutes' bench.
West Ham United XI: Fabianski; Wan-Bissaka, Kilman, Mavropanos, Emerson; Soucek, Alvarez, Soler; Kudus, Bowen, Summerville
Subs: Areola, Cresswell, Coufal, Paqueta, Fullkrug, Guilherme, Ings, Rodriguez, Todibo
Wolverhampton Wanderers XI: Johnstone; Doherty, Semedo, Bueno, Toti, Ait-Nouri; Andre, Lemina, Gomes; Cunha, Strand Larsen
Subs: Bentley, Hwang, Dawson, R.Gomes, Forbs, Bellegarde, Guedes, Lima
Written by
Darren Plant