Footage first emerged on social media of Coote's x-rated comments about former Liverpool boss Jurgen Klopp, who he called a 'German c***'.
The 42-year-old was suspended before another video was released of him snorting white powder during Euro 2024.
Coote was then alleged to have discussed giving a yellow card before and after a match between Leeds United and West Brom.
As well as this, he reportedly sent messages abut organising a 'drugs party' during Tottenham and Manchester City's Carabao Cup match in October.
A PGMOL statement reads: "Following the conclusion of a thorough investigation into David Coote's conduct, his employment with PGMOL has been terminated today with immediate effect.
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"David Coote's actions were found to be in serious breach of the provisions of his employment contract, with his position deemed untenable.
"Supporting David Coote continues to be important to us and we remain committed to his welfare.
"David Coote has a right to appeal the decision to terminate his employment."
Coote has refereed 112 Premier League matches during his career, with his first outing coming in April 2018.
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He has also officiated in the Championship, League One and League Two, as well as the FA Cup and Carabao Cup.
More to follow...