Both teams are looking to bounce back from midweek defeats, with the Hammers losing 3-0 to Manchester City and United falling to Brighton.
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West Ham's third defeat on the bounce has left them in 15th, only four points outside the relegation zone with four games left.
United, meanwhile, saw their five-game Premier League unbeaten run end thanks to Alexis Mac Allister's 99th minute penalty.
The Red Devils remain in fourth but the gap to Liverpool could be cut to just one point if the Reds beat Brentford before they play - although Erik ten Hag's men would still have two games in hand.
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West Ham v Man United: talkSPORT coverage
This Premier League clash will take place on Sunday, May 7.
Kick-off at the London Stadium is scheduled for 7pm.
talkSPORT will have live and EXCLUSIVE coverage from east London, with Adrian Durham serving as your host.
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Commentary will then come from Sam Matterface and former West Ham defender Scott Minto.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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West Ham v Man United: Team news
The Hammers are expected to welcome back Declan Rice, Tomas Soucek and Nayef Aguerd from illness that kept them out at the Etihad.
The hosts are still without Kurt Zouma due to an ankle injury and he joins Gianluca Scamacca who is the only other absentee.
As for United, defensive duo Raphael Varane and Lisandro Martinez headline the list of injury concerns Ten Hag is dealing with.
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Donny van de Beek, Alejandro Garnacho, Tom Heaton and Phil Jones are all still sidelined but Scott McTominay could return from a knock.
West Ham v Man United: What has been said?
Following their defeat to Brighton, United boss Ten Hag said: "The last five games until tonight, we had four wins and one draw.
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"So, I think we were in a good run. And I think we are improving.
"As you see also today, if you see [the] first half, we should have gone up [in the game], we didn't do, but we created our chances.
"So, we still have a way to go, [we need to] be more clinical and then we have to stay focused until the end of the game."
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West Ham v Man United: Match facts
Lucas Paquetá has been involved in four goals in his last four home games for West Ham in all competitions (2 goals, 2 assists), double the amount he had in his first 16 at the London Stadium (2 assists).
Three of Marcus Rashford's four Premier League goals against West Ham have been as a substitute, his most goals from the bench against an opponent in the competition.
West Ham manager David Moyes is winless in his last 10 Premier League games against Manchester United (D2 L8), losing the last five in a row. His last win against them was with Everton in August 2012 (1-0).
West Ham have won two of their last three Premier League games on Sundays (D1), beating Southampton 1-0 and Bournemouth 4-0 last month. The Hammers had won just two of their previous 13 league games on Sunday before this (D3 L8).
West Ham are winless in three Premier League home games (D1 L2), conceding nine goals in these matches. The Hammers had been unbeaten in their previous five at the London Stadium (W3 D2), keeping three clean sheets and conceding just twice.
Manchester United have won just one of their last eight Premier League away games against London sides (D3 L4), beating Fulham 2-1 earlier this season. It's as many defeats as they'd suffered in their previous 23 visits to the capital (W12 D7 L4).
West Ham have dropped 35 points from winning positions against Manchester United in the Premier League, more than they have against any other side. Their record when leading against the Red Devils in the competition is W7 D7 L7.
Manchester United have won seven of their last eight meetings with West Ham in all competitions (L1), with this the third consecutive campaign the two sides have met at least three times. The Red Devils have won both this season, and also won all three in 2020-21.
Man Utd have won their last two away league games against West Ham, as many as in their previous eight visits (D3 L3). They last won three in a row at the Hammers between February 2009 and April 2011.
Having won two of their three Premier League games against Man Utd under Manuel Pellegrini (L1), West Ham are winless in their last six against them, losing each of the last five in a row (D1).