The right-back has had a tough season so far under Erik ten Hag, playing only four minutes of competitive football as he has been out of favour under the Dutch manager.
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Wan-Bissaka's last start for Manchester United in a competitive came back in April in the defeat at Everton, and he has been replaced in the first team by Diogo Dalot since then.
Now, West Ham have emerged as serious contenders for his signature and could make a move for him, with the club having a close relationship with his agency, Unique Sports Management, according to Manchester Evening News.
It's believed that West Ham were interested in Wan-Bissaka last summer when the player was told he was free to leave Old Trafford, following a complicated spell.
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The Hammers have a few problems in that position: their two senior options in that role, Vladimir Coufal and Ben Johnson, haven't been able to nail down a regular place while Thilo Kehrer has played there occasionally.
They are keen to amend those issues and the signing of Wan-Bissaka could help them do that, giving manager David Moyes another option for the position and perhaps, a more permanent one.
Ten Hag last month explained why Wan-Bissaka doesn't play regularly, to which he said the right-back "struggles [with] some injuries, some illnesses, so he was also often not available but doesn't have a real big problem".
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It's often been noted that Ten Hag uses Tyrell Malacia - traditionally a left-back - and Victor Lindelof over Wan-Bissaka when Dalot isn't available and that's an indication of his standing in the team.
Other than West Ham, Wan-Bissaka was also linked with a move to Wolves over the past week, giving him an option.
Wan-Bissaka joined in 2019 for a mammoth £45m, potentially rising to £50m, but hasn't delivered on that price tag yet, with his attacking tendencies often criticized.