David Moyes' side have endured a disappointing Premier League campaign but will make amends if they lift the trophy.
Wednesday night could prove to be historic one for the east London side as fans embark on their trip to Czech capital Prague.
One supporter couldn't contain his excitement before his flight took off as he made a cheeky announcement over the tannoy at Stansted Airport.
In a video posted on Twitter, the fan seized the opportunity to have some fun by saying: "This is a staff announcement, West Ham are massive."
READ MORE ON WEST HAM
Have West Ham ever won a major trophy? Hammers aiming for European silverware in Prague
David Moyes latest: Scot could leave West Ham this summer despite European final
Hammers fans are known to chant 'West Ham are massive, everywhere they go!' at games, and clearly now at airports.
Another video caught other fans signing their iconic 'I'm Forever Blowing Bubbles' song on a flight to Prague.
They will undoubtedly be in fine voice at the Eden Arena as West Ham look to win the second ever Europa Conference League title.
Roma were the inaugural winners last season as they saw off Feyenoord in third-highest rated club competition of continental football.
Most read in Football
Redknapp reveals why he rates Postecoglou and says Tottenham players will love him
Leicester announce departures of seven players, including Villa target Tielemans
'The worst 16 hours of my life' - Ex-player of Postecoglou on flight with 'scary' boss
Tottenham poised to confirm appointment of Ange Postecoglou as personal terms agreed
talkSPORT will have live coverage of the Europa Conference League final between West Ham and Fiorentina.