The 31-year-old has had a bright start to the new campaign, scoring four goals and providing three assists in his opening three league matches for the Hammers.
Antonio's brace in West Ham's 4-1 win over Leicester City took the newly-capped Jamaica international onto 49 Premier League goals, two more than club legend Paolo Di Canio, before scoring his 50th in the 2-2 draw against Crystal Palace.
This is the second time the striker has been named as the Player of the Month, with his first award received in July 2020.
Antonio has also become the first West Ham player to win the monthly accolade since Manchester United loanee Jesse Lingard, who took home the award in April.
The former Sheffield Wednesday and Nottingham Forest man fought off competition from fellow nominees Mason Greenwood, Marcos Alonso, Eric Dier, Demarai Gray as well as Hammers teammate Said Benrahma.
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow