Watford are fighting hard to stay in the top-flight this season and held Manchester United to a goalless draw last weekend.
The Hornets must keep picking up points as it continues to be congested at the bottom of the table.
Arsenal, meanwhile, are pushing for a top-four finish this season.
They are in fine form at the moment, seeing off Wolves last time out, and Mikel Arteta will be determined to make no mistakes in Hertfordshire.
Watford v Arsenal: Date and kick-off time
The Premier League clash is due to take place on Sunday, March 6 at Vicarage Road.
Kick off is scheduled for 2pm.
Arsenal beat Watford 1-0 in November's reverse fixture with Emile Smith Rowe scoring the winner and Juraj Kucka being sent off.
Watford v Arsenal: How to follow
This match will be broadcast on Sky Sports Main Event and Sky Sports Premier League with live coverage starting from 1pm.
Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £9.99.
Watford v Arsenal: Teams news
Ismaila Sarr and Kiko Femenia are doubts for Watford and will need late fitness tests.
Ken Sema and Joao Pedro are among those pushing for starts.
Arsenal could welcome back Takehiro Tomiyasu following his calf issue.
Emile Smith Rowe missed the Wolves game but could also return.
The Gunners have no further problems to contend with.
Watford v Arsenal: What has been said?
Watford ace Hassane Kamara: "I think we can stay in the Premier League; it's close between 14 and 20.
"We will try to attack because, now we are better defensively, we have to try to go more offensive and we will have a chance to win any game.
"If we win our games we will stay in the Premier League, we just have to focus on our matches. It will be difficult, but we will focus on the teams ahead of us.
"The connection with the supporters is good. The fans are the club. The club is the players and the fans. In this position, we need the fans because we need them to push the team. For me, it is normal to speak with them.
"It is very important to win at home because you are with your fans, we know the pitch and we know the atmosphere. It is easier to win the game and very important for the club, the fans and all the players."