It was almost the perfect week for Rob Page's side, who qualified for the World Cup in Qatar just three days prior.
Wales dominated most of the first half and didn't seem to be suffering from any hangover after their 1-0 win over Ukraine on Saturday.
It was a 45 minutes that lacked any real quality, which might have had something to do with Gareth Bale starting the game on the bench.
Harry Wilson had a good chance when he went for goal from a free-kick from distance, but his on-target effort lacked pace and was punched away by the Dutch goalkeeper.
Louis van Gaal's side started the second half quickly and it wasn't long before they opened the scoring at the Cardiff City Stadium.
Teun Koopmeiners was given space on the edge of the box to drill a low effort into the bottom corner, which 'keeper Adam Davies - who came on at half-time - could have done better with.
It was actually the Dutch's first shot on target and their lack of creativity was evident.
So the introduction of De Jong was much-needed when he came on with 20 minutes to play and he was set to have an important role in what was a grandstand finish in Cardiff.
Despite it being a game of very few chances, the crowd - who had watched a poor game of football - were finally rewarded for their patience with two stoppage-time goals.
Rhys Norrington-Davies thought he had secured a point for his side in the 91st minute, when he headed home from close range.
But just sixty seconds later, Burnley striker Wout Weghorst also got his head onto a cross to win the game for the visitors.
De Jong played an important part in the goal, driving through midfield to create the chance, which will have excited any Red Devils fans watching.