Spurs were beaten by fellow title challengers Liverpool on Wednesday.
Leicester, who are a point behind Sunday's opponents, also lost that night, going down to Everton.
Both will want to hit back this weekend and get their title tilts back on track.
Tottenham v Leicester: Date and kick-off time
This match will be held at the Tottenham Hotspur Stadium on Sunday, December 20 and will kick-off at 2:15pm.
This fixture ended in a 3-0 win to Tottenham last season with Harry Kane netting a double.
The Foxes beat Spurs at home last September thanks to James Maddison's winner.
Tottenham v Leicester: TV channel and live stream
The game is being broadcast on Sky Sports Main Event and Sky Sports Premier League from 2pm.
Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £8.99.
Tottenham v Leicester: Team news
Tottenham boss Jose Mourinho expects Gareth Bale to be fit to face Leicester.
The Wales international has missed the last two games with illness, but is back in training.
Mourinho said: "He's fine. Trained Thursday with the team and today. He looks OK. If he's OK again tomorrow then he'll be fine."
Tottenham v Leicester: Match stats and facts
Tottenham have won five of their last seven Premier League meetings with Leicester (L2), netting 21 goals across these games.
Leicester have won just one of their last nine Premier League away games against Spurs (D2 L6), winning 1-0 at White Hart Lane in their 2015-16 title-winning season.
Tottenham have only failed to score once in their last 20 Premier League meetings with Leicester, doing so in a 0-1 home loss in January 2016.
Spurs have won their final league match before Christmas in six of their last seven seasons, though they lost 0-2 to Chelsea last season.
After picking up just six points in their first nine away Premier League matches of 2020 (W1 D3 L5), Leicester have won 15 points in their last six games on the road (W5 L1).
Tottenham have lost only one of their last 11 home games in the Premier League (W7 D3), after losing three of their first eight such matches under José Mourinho in the competition (W5 L3).
Leicester boss Brendan Rodgers has faced Jose Mourinho more times without ever winning in all competitions than he has against any other manager in his career (P7 - W0 D2 L5).
Tottenham's Harry Kane has scored 14 goals in just 10 Premier League appearances against Leicester, more than he's netted versus any other opponent in the competition. Only Sergio Aguero (15 vs Newcastle for Man City) has scored more goals for a single club against a specific opponent in the competition's history.
Leicester striker Jamie Vardy has scored 18 goals in his last 18 away Premier League appearances. Vardy has scored away Premier League goals against Spurs at White Hart Lane and Wembley and will be the first player to score away goals against an opponent on three different grounds if he scores against them in this match.
Tottenham's Son Heung-min has been directly involved in seven goals in his last seven Premier League appearances against Leicester, scoring four goals and assisting three more.
Premier League high-fliers Tottenham and Leicester will both be looking to bounce back from their midweek defeats when they face off in London.