The Lilywhites eked out a 1-0 success over Crystal Palace in last weekend's London derby thanks to Harry Kane's 209th goal in the English top flight, which saw him overtake Wayne Rooney into second place in the all-time charts.
That narrow victory keeps Tottenham just about alive in the race for Champions League football in sixth spot, six points behind Manchester United having played a game more, but a dissatisfactory result at Villa Park could end their hopes of a top-four finish.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of the clash with Unai Emery's men, who sit two places and three points worse off than the North London outfit in seventh place.
Hugo Lloris
Status: Out
Type of injury: Hip
Possible return date: Unknown
Mason confirmed before Spurs' win over Palace that Hugo Lloris's hip injury would sideline him for the remainder of the season, and the captain could very well have played in a Tottenham jersey for the final time amid speculation over a new number one arriving at Hotspur Way this summer.
Rodrigo Bentancur
Status: Out
Type of injury: Knee
Possible return date: Unknown
Likewise, Rodrigo Bentancur will not play again this term either due to the ACL injury he suffered against Leicester City back in February, although the Uruguayan is making steady progress in his rehabilitation.
Ryan Sessegnon
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
The luckless Ryan Sessegnon has been struggling to overcome a hamstring problem for the past several weeks, and the Englishman is also confined to the treatment room for the rest of the season.
Clement Lenglet
Status: Minor doubt
Type of injury: Shoulder
Possible return date: May 13 (vs. Villa)
Clement Lenglet was forcibly withdrawn with a shoulder injury in last weekend's success over Palace, but the Barcelona loanee is not believed to have sustained a serious problem and should be available for selection on Saturday.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Tottenham have no players suspended for this match.
Moldova 
Estonia 
Russia 
Zambia 
Azerbaijan 
Belarus 
Sweden 
Northern Ireland 
Gibraltar 
Czechia 
Israel 
Norway 
Liechtenstein 
Kazakhstan 
Montenegro 
Faroe Islands 
North Macedonia 
Wales 
Switzerland 
Luxembourg 
Barcelona 
Osasuna 
Krylya Sovetov 
Lokomotiv Moscow 
Aubagne 
Bordeaux 
Bayer Leverkusen 
VFL Bochum 
Strasbourg 
Lyon 
Gil Vicente 
Benfica 
Obolon-Brovar Kyiv 
Shakhtar Donetsk 
Sampdoria 
Frosinone 
Bayern Munich 
FC ST. Pauli 
Holstein Kiel 
Werder Bremen 
VFL Wolfsburg 
FC Heidenheim 
Celtic 
Heart Of Midlothian 
Espanyol 
Atletico Madrid 
Reims 
Marseille 
Rukh Lviv 
Dynamo Kyiv 
CSKA Moscow 
FK Makhachkala 
Juventus 
Genoa 
Eintracht Frankfurt 
VFB Stuttgart 
Dundee 
Rangers 
ST Etienne 
Paris Saint Germain