Spurs were humiliated 6-1 by Newcastle at the weekend but they can revive their top-four hopes with the visit of the Red Devils.
The north Londoners found themselves 5-0 down after just 21 minutes and after the embarrassing defeat, interim boss Cristian Stellini was sacked with Ryan Mason taking over immediately.
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Tottenham have now dropped down to seventh but can cut the gap to fourth-placed United down to only three points with a win.
Erik ten Hag's men do have two games in hand and victory for them would stretch the gap to an almost insurmountable nine points.
Tottenham XI: Forster, Romero, Dier, Lenglet, Porro, Hojbjerg, Skipp, Perisic, Son, Richarlison, Kane.
Subs: Austin, Tanganga, Sanchez, Sarr, Davies, Mundle, Lucas, Danjuma, Kulusevski.
Man United XI: De Gea, Wan-Bissaka, Lindelof, Shaw, Dalot, Casemiro, Eriksen, Fernandes, Sancho, Antony, Rashford.
Subs: Butland, Malacia, Fred, Williams, Pellistri, Sabitzer, Elanga, Martial, Weghorst.
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