It was the worst possible start for Spurs under Ryan Mason, with Cristian Romero being criticised for his defending for the goal.
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United travelled to north London looking for a win that will boost their hopes of a top four finish.
It didn't take long for them to stamp their mark though, with Sancho firing in a superb shot into the bottom right corner.
The 23-year-old's effort was well struck, but talkSPORT's Scott Minto was left unimpressed with Romero's efforts to block it.
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He said: "It's too simple. It's like the first goal at St James' Park. There are three Spurs players, someone has to stop the shot. Make a block.
"Romero is too busy trying to make sure his hands are behind his back.
"Just get closer to him! Get tighter! It's wonderful from Sancho but it's basic defending."
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talkSPORT commentator Sam Matterface said: "That's embarrassing. It's their first attack. It's Jadon Sancho, you know what he's going to do."
Minto also said: "From Tottenham's point of view, that's a shocking goal. It's basic defending. Let them pass it down the outside. The centre-halves can get themselves ready.
"As soon as you allow a winger to come inside, you're hoping they miss. There's no talking from Romero.
"He's not telling [Pedro] Porro to let it go outside. You expect the centre-back to come across and help make decisions. Romero didn't do that."
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Marcus Rashford made it 2-0 before the break to put United in full control of the clash.
However, Spurs found a goal themselves in the second half when Pedro Porro fired into the top corner.
The hosts drew level late on courtesy of Heung-min Son's scuffed finish at the far post.
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Spurs will be pleased to have at least secured a point, coming back from two goals down to seal the draw.