All three have been in Croatia for the last 10 days in order to circumvent hard quarantine rules following their decision to travel to South America for World Cup qualifiers earlier this month.
Son Heung-min (calf) and Eric Dier (dead leg) are doubts, along with with Steven Bergwijn and Lucas Moura, who both hobbled off in Thursday's Europa Conference League draw at Rennes. Japhet Tanganga (suspended) and Ryan Sessegnon (hamstring) are out.
N'Golo Kante will return for Chelsea after shaking off his latest injury issue.
The France midfielder is fit after ankle trouble, in a significant boost to the Blues.
Christian Pulisic remains sidelined with an ankle complaint of his own however.
Tottenham provisional squad: Lloris, Gollini, Doherty, Emerson, Sanchez, Romero, Dier, Rodon, Reguilon, Davies, Skipp, Hojbjerg, Ndombele, Alli, Bergwijn, Moura, Lo Celso, Gil, Kane, Son, Scarlett.
Chelsea provisional squad: Mendy, Chalobah, Silva, Rudiger, Hudson-Odoi, Kovacic, Niguez, Alonso, Ziyech, Havertz, Lukaku, Arrizabalaga, Christensen, Jorginho, Kante, Werner, Loftus-Cheek, Barkley, James, Mount, Chilwell, Azpilicueta, Sarr.
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow