The Lilywhites occupy fifth place but can break into the top four in favourable circumstances, while David Moyes's men are languishing in 16th - just two points above the drop zone - and here Sports Mole rounds up the team news for both clubs.
TOTTENHAM HOTSPUR vs. WEST HAM UNITED
TOTTENHAM HOTSPUR
Out: Rodrigo Bentancur (ACL), Yves Bissouma (ankle), Hugo Lloris (knee), Ryan Sessegnon (hamstring)
Doubtful: None
Sports Mole's predicted XI: Forster; Romero, Dier, Davies; Emerson, Sarr, Hojbjerg, Perisic; Richarlison, Kane, Son
WEST HAM UNITED
Out: Lucas Paqueta (shoulder), Gianluca Scamacca (knee), Maxwel Cornet (calf), Alphonse Areola (thigh), Kurt Zouma (thigh)
Doubtful: Nayef Aguerd (groin), Aaron Cresswell (illness)
Sports Mole's predicted XI: Fabianski; Kehrer, Ogbonna, Cresswell; Coufal, Rice, Soucek, Emerson; Bowen, Antonio, Benrahma
For data analysis of the most likely results, scorelines and more for this match please click here.