Proceeds from the match will go towards Shakhtar Social - a foundation working to support those affected by the Russian invasion - and here Sports Mole rounds up the team news for both clubs.
TOTTENHAM HOTSPUR vs. SHAKHTAR DONETSK
TOTTENHAM HOTSPUR
Out: Bryan Gil (groin), Rodrigo Bentancur (ACL), Ryan Sessegnon (hamstring)
Doubtful: Yves Bissouma (ankle)
Sports Mole's predicted XI: Austin; Emerson, Romero, Davies, Reguilon; Sarr, Skipp, Lo Celso; Solomon, Richarlison, Perisic
SHAKHTAR DONETSK
Out: Valeriy Bondar (collarbone), Georgiy Sudakov (appendicitis), Ivan Petryak (ankle)
Doubtful: None
Sports Mole's predicted XI: Trubin; Gocholeishvili, Kozik, Matvienko, Pedrinho; Bondarenko, Castillo; Zubkov, Sikan, Newerton; Traore
For data analysis of the most likely results, scorelines and more for this match please click here.