Spurs head into this encounter after being blown away by North London rivals Arsenal, who claimed a 3-1 Premier League victory at the Emirates Stadium last weekend.
Only left-back Sergio Reguilon and midfielder Dele Alli retain their places in the first XI, with the latter wearing the captain's armband.
Italian goalkeeper Pierluigi Gollini is brought into the starting lineup, replacing club captain Hugo Lloris between the sticks, while defeneders Matt Doherty, Cristian Romero and Joe Rodon all start, with Japhet Tanganga, Eric Dier and Davinson Sanchez dropping to the bench.
Oliver Skipp, Harry Winks and Giovani Lo Celso will operate in central midfield, while Pierre-Emile Hojbjerg and Tanguy Ndombele are options for Nuno as substitutes.
Dele could be set to feature in a more advanced midfield role, linking up with winger Bryan Gil and teenager forward Dane Scarlett. Harry Kane and Lucas Moura - who started in Tottenham's opening Group G match against Rennes and on Sunday against Arsenal - both begin on the bench tonight, as does Son Heung-min.
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AZ Alkmaar 
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Liverpool 
Como 
Fiorentina 
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Rayo Vallecano 
Ajax 
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Palermo 
Sampdoria 
Ipswich 
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FC Porto 
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