The Red Devils beat Everton 3-1 in the previous round, while the Royals secured a 2-0 victory against Watford, and here, Sports Mole rounds up all of the latest team news for the two clubs.
MANCHESTER UNITED vs. READING
MANCHESTER UNITED
Out: Diogo Dalot (hamstring), Axel Tuanzebe (back), Donny van de Beek (knee)
Doubtful: Luke Shaw (illness), Anthony Martial (leg), Jadon Sancho (fitness)
Sports Mole's predicted XI: Heaton; Wan-Bissaka, Lindelof, Maguire, Malacia; McTominay, Fred, Mainoo; Elanga, Weghorst, Garnacho
READING
Out: Andy Carroll (ankle), Naby Sarr (knee), Sam Hutchinson (Achilles), Liam Moore (hamstring)
Doubtful: Ovie Ejaria (other)
Sports Mole's predicted XI: Lumley; Yiadom, Holmes, McIntyre; Hoilett, Hendrick, Fornah, Loum, Baba; Ince, Joao
For data analysis of the most likely results, scorelines and more for this match please click here.