The Red Devils are currently third in the table with seven points, while Newcastle sit in 17th with just a single point, and here Sports Mole rounds up the team news for the two sides.
MANCHESTER UNITED vs. NEWCASTLE UNITED
MANCHESTER UNITED
Out: Fred (suspended), Marcus Rashford (shoulder)
Doubtful: Alex Telles (fitness), Dean Henderson (fitness), Phil Jones (fitness), Scott McTominay (groin)
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Van de Beek, Pogba; Greenwood, Fernandes, Sancho; Ronaldo
NEWCASTLE UNITED
Out: Martin Dubravka (foot), Jonjo Shelvey (calf), Callum Wilson (thigh), Ryan Fraser (ankle), Elliott Anderson (groin)
Doubtful: Isaac Hayden (knee), Paul Dummett (calf), Karl Darlow (illness)
Sports Mole's predicted XI: Woodman; Fernandez, Lascelles, Schar; Murphy, Willock, Hayden, Almiron, Ritchie; Saint-Maximin, Joelinton