Unai Emery's huge influence since arriving as Villa's manager means they are just six points behind United in fourth ahead of this fixture, and here Sports Mole rounds up the team news for both clubs.
MANCHESTER UNITED vs. ASTON VILLA
MANCHESTER UNITED
Out: Lisandro Martinez (foot), Raphael Varane (ankle), Donny van de Beek (knee), Phil Jones (knee), Tom Heaton (ankle), Alejandro Garnacho (ankle)
Doubtful: Harry Maguire (knock), Scott McTominay (knee)
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Lindelof, Shaw, Dalot; Casemiro, Eriksen, Fernandes; Antony, Rashford, Sancho
ASTON VILLA
Out: Leon Bailey (hamstring), Matty Cash (calf), Boubacar Kamara (ankle), Philippe Coutinho (thigh), Jed Steer (muscle)
Doubtful: None
Sports Mole's predicted XI: Martinez; Young, Konsa, Mings, Alex Moreno; Dendoncker, Douglas Luiz, McGinn, Buendia, Ramsey; Watkins
For data analysis of the most likely results, scorelines and more for this match please click here.