John Ruddy, Leander Dendoncker, Yerson Mosquera and Fabio Silva may all come in following the 2-0 Premier League defeat to Brentford.
Jonny (knee) and Pedro Neto (knee) remain long-term absentees for Wolves boss Bruno Lage.
Tottenham will be without forwards Steven Bergwijn and Lucas Moura.
Bergwijn has a sprained ankle while Moura has a knock and both men will not make the trip to the midlands.
Defender Japhet Tanganga is back from suspension and should return to the squad.
Wolves provisional squad: Sa, Ruddy, Kilman, Coady, Saiss, Boly, Hoever, Mosquera, Semedo, Ait-Nouri, Marcal, Neves, Cundle, Moutinho, Dendoncker, Trincao, Traore, Podence, Silva, Hwang, Jimenez.
Tottenham provisional squad: Lloris, Gollini, Doherty, Emerson, Sanchez, Romero, Tanganga, Dier, Rodon, Reguilon, Davies, Skipp, Hojbjerg, Ndombele, Alli, Lo Celso, Gil, Kane, Son, Scarlett.