Spurs, who currently sit 10th in the Premier League table, have won just one of their last 28 top-flight away encounters against the Gunners and lost 2-1 in this fixture last season.
Nuno has been boosted by the return of Lucas Moura, who is named in today's starting lineup, however Steven Bergwijn remains out with an ankle injury, while Ryan Sessegnon is nursing a hamstring problem.
Captain Hugo Lloris returns between the sticks, replacing Italian goalkeeper Pierluigi Gollini, who started in the EFL Cup victory against Wolverhampton Wanderers in midweek.
Centre-back Cristian Romero and left-back Ben Davies drop out of the starting lineup and are replaced by Eric Dier and Sergio Reguilon respectively.
Dele Alli and Tanguy Ndombele retain their midfield roles, while Pierre-Emile Hojbjerg starts ahead of Oliver Skipp, who takes his place on the substitutes bench alongside fellow midfielders Giovani Lo Celso and Bryan Gil.
Moura is joined in attack by Son Heung-min and talisman Harry Kane, who is bidding to become the highest Premier League goalscorer against Arsenal.
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow