Meanwhile, Antonio Conte's third-placed side can replace the Gunners at the summit with victory in the lunchtime clash, and here Sports Mole rounds up the team news for both clubs.
ARSENAL vs. TOTTENHAM HOTSPUR
ARSENAL
Out: Mohamed Elneny (hamstring), Cedric Soares (knock), Emile Smith Rowe (groin)
Doubtful:Kieran Tierney (head), Oleksandr Zinchenko (calf), Thomas Partey (knee), Reiss Nelson (thigh)
Sports Mole's predicted XI: Ramsdale; White, Saliba, Gabriel, Zinchenko; Xhaka, Partey; Saka, Odegaard, Martinelli; Jesus
TOTTENHAM HOTSPUR
Out: None
Doubtful: Hugo Lloris (thigh), Ben Davies (knee), Lucas Moura (tendon), Dejan Kulusevski (hamstring)
Sports Mole's predicted XI: Lloris; Romero, Dier, Lenglet; Perisic, Bentancur, Hojbjerg, Sessegnon; Richarlison, Kane, Son
For data analysis of the most likely results, scorelines and more for this match please click here.