The Gunners - who are top of the section with six points - will go through with a win if Lens also get the better of PSV Eindhoven, and here Sports Mole rounds up the team news for both clubs.
ARSENAL vs. SEVILLA
ARSENAL
Out: Jurrien Timber (knee), Emile Smith Rowe (knee), Thomas Partey (muscle), Gabriel Jesus (hamstring)
Doubtful: Martin Odegaard (hip), Eddie Nketiah (knock)
Sports Mole's predicted XI: Raya; White, Saliba, Gabriel, Zinchenko; Vieira, Jorginho, Rice; Saka, Trossard, Martinelli
SEVILLA
Out: Marcao (adductor), Alfonso Pastor (knee), Sergio Ramos (calf), Marcos Acuna (hamstring), Orjan Nyland (quadriceps)
Doubtful: None
Sports Mole's predicted XI: Dmitrovic; Navas, Gudelj, Bade, Pedrosa; Rakitic, Soumare, Sow; Lukebakio, En-Nesyri, Ocampos
For data analysis of the most likely results, scorelines and more for this match please click here.