The Gunners remain five points clear of Manchester City in first place, while the managerless Eagles sit 12th following a 1-0 loss to Brighton & Hove Albion in midweek, and here Sports Mole rounds up the team news for both clubs.
ARSENAL vs. CRYSTAL PALACE
ARSENAL
Out: Mohamed Elneny (knee), Takehiro Tomiyasu (knee), Eddie Nketiah (ankle)
Doubtful: William Saliba (back)
Sports Mole's predicted XI: Ramsdale; White, Holding, Gabriel, Tierney; Odegaard, Partey, Xhaka; Saka, Trossard, Martinelli
CRYSTAL PALACE
Out: Albert Sambi Lokonga (ineligible), Nathan Ferguson (fitness), Sam Johnstone (calf)
Doubtful: Vicente Guaita (hamstring), Will Hughes (illness), James McArthur (illness)
Sports Mole's predicted XI: Whitworth; Clyne, Andersen, Guehi, Mitchell; Hughes, Doucoure, Schlupp; Olise, Edouard, Zaha
For data analysis of the most likely results, scorelines and more for this match please click here.