Bournemouth's deserved 3-0 win on Saturday is a prime example of this as United face a statistic that makes for grim reading.
Defeat against the Cherries was their 35th loss in the Premier League at Old Trafford since Sir Alex Ferguson left as manager in 2013.
In contrast, United lost just 34 times at home throughout the 21 seasons the legend spent at the club.
Four of the aforementioned 35 defeats have come this season, with the club once again going through a fluctuant period of form.
Bournemouth got no less than they deserved, but talkSPORT pundits have lamented United for how they performed.
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Speaking on the GameDay Phone-In, Gabby Agbonlahor said: "They were battered! I'm still in shock!
"They got such a positive result against Chelsea, but I knew this would happen today, because Chelsea were absolutely miles off it, so Man United probably went out there thinking they would walk it, but they got schooled by Bournemouth in every department.
"They were defensively so poor and poor in attack as well. Manchester United have scored 18 goals in 16 games, compared to Liverpool 36, Man City 36, Aston Villa 34, Wolves and Fulham 21, Luton have only scored two goals less than United.
"Of those 18 goals, five have been Scott McTominay, Bruno Fernandes has three, Rasmus Hojlund is still on zero, Antony on zero - I bet they don't even score in training, they just can't get a goal out of them! They are not good enough!"
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Jamie O'Hara was also in alignment that United were not up to scratch: "They were embarrassing.
"It was unbelievable. They were pumped by Bournemouth. Not beat just like a goal to nil, they have been absolutely pumped… by Bournemouth.
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"Manchester United were a disgrace today, the players out there were a disgrace to wear that shirt, half the ground was empty at the final whistle and the performance they put in, they should be ashamed of themselves tonight.
"Marcus Rashford was on the bench probably thinking, 'Don't even bother putting me on gaffer', and Jadon Sancho is probably at fashion week. It really was shocking."
United have tasted defeat seven times in the Premier League this season, with their total tally across all competitions at 11.
Erik ten Hag's side will now prepare for two monumental fixtures, with a win against Bayern Munich needed to offer hope of qualifying for the Champions League last 16.
A huge clash away at Liverpool follows, with the Reds firm contenders for this season's Premier League title.