The Blues will enter the match off the back of a 5-1 victory over struggling Southampton in England's top flight.
Chelsea's excellent form has seen them rise into second spot in the Premier League table, level on points with third-placed Arsenal and seven from the leaders Liverpool, who dropped two points against Newcastle United on Wednesday night.
Here, Sports Mole rounds up the away team's latest injury and suspension news ahead of a trip to the Tottenham Hotspur Stadium for a London derby.
Wesley Fofana
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Fofana picked a hamstring injury in the recent win over Aston Villa, and Chelsea head coach Enzo Maresca has confirmed that the centre-back will miss the next four to five weeks with the problem.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
James, who has been restricted to just four appearances this term due to injury issues, is currently recovering from his latest hamstring problem, and a return before the end of the year is seen as unlikely.
Omari Kellyman
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Kellyman, who arrived at Chelsea from Villa over the summer, is yet to feature for the Blues due to a troublesome hamstring problem, and the 19-year-old is not expected to be available for selection until 2025.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspension issues heading into this contest.
Written by
Matt Law