Pep Guardiola's side lost their grip on first place in the Premier League table on Saturday afternoon, suffering their first defeat in the top flight in 32 games with a 2-1 reverse at Bournemouth.
However, the Citizens are yet to come out on the wrong end of the scoreline in Europe this term, taking seven points from their first three games to lie third in the Champions League table behind Aston Villa and Liverpool.
Here, Sports Mole rounds up Man City latest injury and suspension news ahead of the contest with Sporting, who are eighth in the 36-team table but will soon be waving goodbye to Manchester United-bound manager Ruben Amorim.
Rodri
Status: Out
Type of injury: Knee
Possible return date: Unknown
Rodri sported his crutches as he collected his 2024 Ballon d'Or award in Paris last week, as the Spaniard recovers from the ACL injury that has ruled him out for the rest of the campaign.
Oscar Bobb
Status: Out
Type of injury: Leg fracture
Possible return date: January 4 (vs. West Ham United)
Likewise, Oscar Bobb is on the long road to recovery from the leg fracture he sustained in pre-season, and Guardiola has confirmed that the young winger is eyeing a comeback in either January or February.
Jack Grealish
Status: Out
Type of injury: Unspecified
Possible return date: Unknown
Jack Grealish has spent the past couple of weeks in the treatment room with an unspecified concern, and Guardiola has suggested that the English attacker will not return this side of the international break.
Ruben Dias
Status: Out
Type of injury: Unspecified
Possible return date: Unknown
Ruben Dias was a casualty of the recent EFL Cup loss at Tottenham Hotspur, and Guardiola has now revealed that the Portuguese will be out for "a little bit of a long time" with that unspecified concern.
John Stones
Status: Out
Type of injury: Unspecified
Possible return date: Unknown
Guardiola was equally cryptic when discussing John Stones's absence at full time on Saturday; the 30-year-old played the full 90 against Tottenham before missing out on selection against Bournemouth, and he will not be available here either.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow