At the age of just 16 years and 353 days, Barcelona prodigy Yamal became the youngest-ever player to feature in the knockout rounds of a European Championship when he started and registered an assist in Spain's 4-1 comeback victory over Georgia in the last 16.
Yamal is now bidding to become the youngest-ever player to feature in a quarter-final tie on the continental stage and could become the youngest-ever goalscorer in Euros history if he makes the net ripple on Friday.
The teenage wonderkid is expected to retain his spot on the right side of a front three next to captain and striker Alvaro Morata, and in-form winger Nico Williams who scored and assisted during a scintillating display against Georgia.
Both Fabian Ruiz and Rodri were also on the scoresheet and are set to link arms with Pedri in centre-midfield, although Dani Olmo - another goalscorer against Georgia - Mikel Merino and Fermin Lopez will be among those hoping to force their way into the first XI.
Nacho Fernandez has recovered from a minor foot injury to make himself available for selection, but the ex-Real Madrid man is unlikely to displace either of Aymeric Laporte or Robin Le Normand in central defence, while Dani Carvajal and Marc Cucurella should continue as full-backs.
Spain possible starting lineup: Simon; Carvajal, Le Normand, Laporte, Cucurella; Pedri, Rodri, Ruiz; Yamal, Morata, Williams