The Lilywhites require just a point to secure a fifth-placed finish and Europa League qualification, but their Champions League hopes evaporated in a 2-0 midweek loss to Manchester City.
Richarlison (calf), Yves Bissouma (knee), Manor Solomon (knee), Fraser Forster (foot), Destiny Udogie (thigh), Ryan Sessegnon (hamstring), Ben Davies (calf) and Timo Werner (thigh) were all unavailable for that game, and the injured octet will miss the final day of the season too.
The defeat to Man City saw Postecoglou finally bow to demands to start Micky van de Ven at left-back, having previously expressed a reluctance to do so due to the Dutchman's fitness struggles this term.
As a result, Van de Ven should reprise that role on Sunday, allowing Radu Dragusin to partner Cristian Romero in the centre, while ever-present right-back Pedro Porro will also be tasked with shielding Guglielmo Vicario.
Postecoglou played it safe in midweek with the inclusions of Rodrigo Bentancur, Pape Sarr and Pierre-Emile Hojbjerg, but the former lasted just 55 minutes and took his frustrations out on a chair after being taken off.
Bentancur is certainly a candidate for the axe here, as Dejan Kulusevski - scorer of a last-gasp winner against the Blades in September - looks to rejoin Son Heung-min, James Maddison and Brennan Johnson in the final third; teenage talent Mikey Moore must wait his turn.
Tottenham Hotspur possible starting lineup:
Vicario; Porro, Romero, Dragusin, Van de Ven; Sarr, Hojbjerg; Kulusevski, Maddison, Johnson; Son