The Citizens suffered a 3-2 defeat to the reigning European champions in their first meeting in Manchester last week.
However, Pep Guardiola's side will enter this match off the back of a morale-boosting result, having beaten Newcastle United 4-0 in the Premier League on Saturday afternoon.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the contest with Real Madrid, who drew 1-1 with Osasuna in La Liga in their last match.
Rodri
Status: Out
Type of injury: Knee
Possible return date: Unknown
Rodri has been named in Man City's squad for the Champions League knockout stages, suggesting that he might be back from his ACL injury before the end of the campaign, but it is still more likely that he will be absent until the 2025-26 season.
Ruben Dias
Status: Minor doubt
Type of injury: Muscle
Possible return date: February 19 (vs. Real Madrid)
Dias was not involved against Newcastle due to muscular fatigue, but the centre-back is expected to be cleared in time to take to the field for the first whistle against Real Madrid.
Nathan Ake
Status: Minor doubt
Type of injury: Muscle
Possible return date: February 19 (vs. Real Madrid)
Ake, like Dias, was not fully-fit for the clash with Newcastle and was left out of the squad, but the Netherlands international should be available for the contest in the Spanish capital.
Jack Grealish
Status: Major doubt
Type of injury: Groin
Possible return date: February 19 (vs. Real Madrid)
Grealish had to be substituted in the first half of the clash with Real Madrid last week due to an apparent groin problem, and the England international is a major doubt for the game in Madrid.
Manuel Akanji
Status: Out
Type of injury: Abductor
Possible return date: Unknown
Akanji had to be replaced at the interval of the clash with Real Madrid due to an abductor issue, and the Switzerland international is now set to be on the sidelines until the end of April.
Oscar Bobb
Status: Major doubt
Type of injury: Leg fracture
Possible return date: February 19 (vs. Real Madrid)
Bobb is now extremely close to making his return from the leg fracture he sustained in the summer, and there is a chance that the highly-rated attacker could be in the squad for the clash with Real Madrid.
Erling Haaland
Status: Minor doubt
Type of injury: Knee
Possible return date: February 19 (vs. Real Madrid)
Haaland was forced off in the latter stages of Saturday's clash with Newcastle due to a slight knee issue, but Guardiola said after the match that the Norway international should be available.
MANCHESTER CITY'S SUSPENSION LIST
Man City have no players suspended for this match.
Written by
Matt Law