The ex-Villarreal shot-stopper - who knows Los Blancos all too well from his time in La Liga - was an unused substitute in Saturday's 4-2 loss to Manchester City after coming off the bench against America for his Blues baptism.
After Robert Sanchez conceded four to the Premier League champions, Jorgensen has every right to feel optimistic of a start on Tuesday, as Enzo Maresca has chopped and changed throughout pre-season.
Reece James and Levi Colwill will likely continue in the backline, but Ben Chilwell and Benoit Badiashile might be considered for starts over Malo Gusto and Tosin Adarabioyo; the latter was not up to scratch against Man City.
Moises Caicedo was also at fault for Erling Haaland's second of three goals following his return from a post-Copa America holiday, so Enzo Fernandez and Kiernan Dewsbury-Hall might pair up in the deeper midfield slots.
Dewsbury-Hall started in the final third alongside Mykhaylo Mudryk and Christopher Nkunku on Saturday, and the Frenchman could reprise his role, but Noni Madueke, Raheem Sterling and Marc Guiu are ready to provide some fresh legs.
Axel Disasi and Nicolas Jackson remain out injured, while Cole Palmer, Marc Cucurella and Conor Gallagher are still on a break after reaching the Euro 2024 final.
Chelsea possible starting lineup:
Jorgensen; James, Badiashile, Colwill, Chilwell; Dewsbury-Hall, Fernandez; Madueke, Nkunku, Sterling; Guiu