Yoro only completed a switch to the 20-time English champions on Thursday evening, with Man United winning the race to secure his services from Lille.
The 18-year-old trained on Friday, and he has now come straight into the starting side for Man United's second pre-season friendly of the summer against Rangers.
Yoro, who will wear the number 15 for the Red Devils, is set to operate alongside the experienced Jonny Evans in the middle of the defence.
There is also big news when it comes to Jadon Sancho, with the Englishman also named in the starting side after patching-up his relationship with head coach Erik ten Hag.
Sancho will also start for Man United against Rangers
Sancho has not featured for Man United since the end of August, but he will take to the field here.
There is also a return between the sticks for Andre Onana, who was not involved in the team's 1-0 defeat to Rosenborg last time out.
Amad Diallo is another starter, while Casemiro, Mason Mount and Ethan Wheatley keep their spots in the XI on Saturday afternoon.
Marcus Rashford is a notable absentee, with the forward not in the squad, while Harry Maguire is still recovering from the muscular problem that forced him to miss the end of last season.
Man United are also still without their players involved in international action his summer, including new signing Joshua Zirkzee.
MAN UNITED XI vs. Rangers: Onana; Wan-Bissaka, Yoro, Evans, Murray; Collyer, Casemiro, Mount; Amad, Wheatley, Sancho