Just three points separates the teams heading into this contest, which should make for an entertaining affair.
Match preview
San Lorenzo booked their place in next round of the Copa Sudamericana when they ran out 4-1 winners against Estudiantes Merida at the Estadio Pedro Bidegain on Tuesday evening.
A brace from Adam Bareiro as well as goals from Malcom Braida and Nahuel Barrios, helped provide the three-goal swing that the Saints needed to finish in second place in Group H, and they also received some help from Fortaleza, who beat Palestino 2-1.
The Saints' attention now turns back to domestic matters where Ruben Insua's side are winless in their last four, drawing three of those games and only scoring once during that time.
Bareiro's 58th-minute strike helped salvage a point against Estudiantes last time out and marked San Lorenzo's first goal in the league since the 2-0 victory over Instituto on May 20.
The Saints have had problems scoring goals throughout the entire season, as they have the scored the fewest amount of goals in the top 10 at this stage, alongside Belgrano.
Despite that, San Lorenzo have been brilliant defensively, conceding just eight times across their 21 league games at this point, proving how tough they are to break down.
After finishing 20th in the league last season, Rosario are having a much better campaign this time around, currently in sixth place on 35 points after 21 matches.
Their 1-1 stalemate with Colon last time out means that Miguel Angel Russo's side are now on a three-game unbeaten streak, preserving their excellent home record in the process.
Canalla currently have the fourth-best home record of any team in the Primera Division this season and are one of only two sides, along with San Lorenzo, that are still unbeaten on home soil after 11 matches, with eight wins and three draws.
However, playing away from home has been a completely different story, as Rosario have only mustered one win on their travels this season, picking up eight points in 10 games - only four teams have picked up fewer points on the road.
San Lorenzo Argentine Primera Division form:
W
W
L
D
D
D
San Lorenzo form (all competitions):
L
D
D
D
D
W
Rosario Central Argentine Primera Division form:
D
W
L
W
D
D
Rosario Central form (all competitions):
Team News
Adam Bareiro has scored three in his last two matches and given San Lorenzo's recent woes in front of goal, the Paraguayan looks set to keep his place up top.
Nahuel Barrios looks set to retain his place on the left flank, while Federico Gattoni, Rafael Perez and Gaston Hernandez will make up a three-man defence.
As for the visitors, Walter Montoya remains the only notable absentee for Russo's side and is likely to be out for a while longer with a ruptured ankle ligament.
Francis Mac Allister will return from suspension after picking up his fifth yellow card of the season against Barracas Central while talisman Alejo Veliz should lead the line for Canalla.
San Lorenzo possible starting lineup:
Batalla; Perez, Gattoni, Hernandez; Giay, Maroni, Elias, Campi; Leguizamon, Barrios, Bareiro
Rosario Central possible starting lineup:
Broun; Martinez, Mallo, Quintana, Rodriguez; Ortiz, O'Connor, Campaz, Malcorra, Giaccone; Veliz
We say: San Lorenzo 1-0 Rosario Central
Given San Lorenzo's struggles in front of goal and Rosario's poor away form, we think this will be a low-scoring affair.