The visitors will also be looking to return to winning ways after picking up just a point from their last two matches.
Match preview
No side has won more Eliteserien titles than Rosenborg, who have been crowned champions of Norway on 28 occasions, but there is little chance that they will add to that tally this term.
Rather than focusing on a title push, Rosenborg have a relegation battle on their hands, having picked up just 13 points from as many games, leaving them four points clear of the bottom three.
Since beating HamKam 4-0 on June 4, interim boss Svein Maalen have played out a 2-2 draw with Stabaek and suffered consecutive defeats to Sarpsborg and Aalesund.
Having failed to win any of their six away league games this season, Rosenborg will be grateful to have home advantage for Sunday's encounter.
The hosts have enjoyed success in recent home head-to-head meetings, winning seven of their last nine home games against Lillestrom.
Lillestrom, meanwhile, head into the weekend in seventh position, having picked up 17 points from their 11 league matches.
After beginning their top-flight campaign with four wins in six matches, Lillestrom have only mustered one victory in their previous five Eliteserien fixtures.
In their most outing, the Canaries suffered a narrow 1-0 defeat to Tromso, representing their third loss in four home games.
The Canaries will head on their travels for Sunday's encounter, where they will be looking to extend their unbeaten away league run to four matches (W2, L2).
Having avoided defeat in all five league games where they have netted the opener (W4, D1), the first goal could be crucial if Lillestrom are to claim a positive result.
Rosenborg Norwegian Eliteserien form:
W
L
W
D
L
L
Rosenborg form (all competitions):
Lillestrom Norwegian Eliteserien form:
W
L
D
W
D
L
Lillestrom form (all competitions):
Team News
Markus Henriksen, Isak Thorvaldsson and Jonathan Augustinsson are all expected to miss out for the hosts through injury.
They are also unable to call upon the services of Jayden Nelson, who is currently representing Canada at the Gold Cup.
After being introduced as a half-time substitute against Aalesund, Adrian Pereira could be presented with a starting place.
As for the visitors, injury issues could prevent Lars Mogstad Ranger and Martin Ove Roseth from featuring against Rosenborg.
Despite suffering a narrow defeat against Tromso, Lillestrom boss Geir Bakke could opt for consistency and name an unchanged lineup.
Having scored 10 goals in 11 league appearances, Akor Adams will be looking to continue his impressive form when he leads the line alongside Thomas Olsen.
Rosenborg possible starting lineup:
Hansen; Reitan, Rogers, Jenssen, Tagseth; Skarsem, Vaananen, Bjorlo; Holse, Ingason, Saeter
Lillestrom possible starting lineup:
Hedenstad; Garnas, Gabrielsen, Skjaervik; Edh, Ibrahimaj, Hoff, Asen, Dragsnes; Adams, Olsen