The home side are currently second in the table, eight points behind division leaders Barcelona, while Atletico occupy fourth position, just four points ahead of fifth-placed Real Betis in the race for the top four.
Match preview
Real Madrid do not have much room for error in La Liga due to Barcelona's stunning form, with the reigning champions currently second in the table, eight points behind the division leaders, who will next be in league action away to Almeria on Sunday evening.
Carlo Ancelotti's side must keep winning and hope that Barcelona slip up, and the home team will enter this match off the back of five straight victories in all competitions, including successes over Al Ahly and Al-Hilal in Morocco earlier this month to win the 2022 Club World Cup.
Real Madrid have also won their last two in the league against Elche and Osasuna, scoring six times and conceding zero, while they recorded a standout victory in the Champions League on Tuesday night, beating Liverpool 5-2 in the first leg of their last-16 affair at Anfield.
Los Blancos were actually two goals behind to the Reds in the early stages but then went on to score five times without reply to place themselves in a strong position to reach the quarter-finals of the competition.
Ancelotti's team will also have one eye on their Copa del Rey semi-final first leg with Barcelona on March 2, with the capital giants fighting for three major trophies in the closing months of the campaign.
Real Madrid - unbeaten at home in the league in 2022-23 - recorded a 2-1 victory over Atletico in the reverse game at Wanda Metropolitano earlier this season, while they were 2-0 winners when the two sides locked horns for the corresponding fixture last term.
Atletico have not beaten Real Madrid at Bernabeu in La Liga since 2016, which is an indication of the size of their task in this match, but Diego Simeone's side will be the fresher of the two teams.
Indeed, the Red and Whites are not playing European football at the moment following their disappointing Champions League group-stage campaign, which saw them finish bottom of their section; Atletico were also knocked out of the Copa del Rey by Real Madrid in the quarter-finals at the end of January.
As a result, the club only have La Liga football to worry about for the rest of the season, and their full focus will be on claiming a top-four position. As it stands, they are fourth in the table, four points clear of fifth-placed Real Betis and just two points behind Real Sociedad in third, with the team recording a 1-0 victory over Athletic Bilbao last weekend courtesy of a second-half effort from Antoine Griezmann.
Atletico are not close to being in a title race this term, though, sitting 18 points behind leaders Barcelona, while they are 10 from second-placed Real Madrid on the same number of matches (22).
Simeone's future as head coach continues to be called into question, with the Argentine thought to be considering leaving his position at the end of the campaign.
There is no getting away from the fact that it has been a disappointing season for Colchoneros, but they have the fourth-best away record in La Liga this season, winning seven of their 11 matches, collecting 23 points in the process.
Real Madrid La Liga form:
W
D
W
L
W
W
Real Madrid form (all competitions):
L
W
W
W
W
W
Atletico Madrid La Liga form:
D
W
W
D
W
W
Atletico Madrid form (all competitions):
W
L
W
D
W
W
Team News
Real Madrid will again be missing Ferland Mendy due to a hamstring problem, while Mariano Diaz is a doubt with the muscular issue that ruled him out of the trip to Liverpool.
Aurelien Tchouameni is back in training after recovering from the flu, though, and the France international could come back into central midfield for Saturday's contest.
David Alaba and Rodrygo suffered injuries against Liverpool, meanwhile, and both have been ruled out of this match, with suggestions that the former could be out for a month with a hamstring injury; Rodrygo is also facing up to 10 days out with a gluteal issue.
Nacho could therefore feature at left-back, while Federico Valverde might be moved further forward into the front three, with Toni Kroos and Eduardo Camavinga potentially joining Tchouameni in the middle, with Luka Modric's fitness being carefully managed at a key stage of the campaign.
As for Atletico, Rodrigo de Paul will be absent with the muscular problem that he suffered against Athletic last time out, while Thomas Lemar is also expected to miss out through injury.
The visitors will be boosted by the return of Stefan Savic from suspension, though, with the experienced centre-back likely to replace Jose Gimenez in the starting side.
Pablo Barrios could be the player to replace De Paul in the middle, while Simeone is expected to make a change in his forward line, with Alvaro Morata, who has had two separate spells at Real Madrid, potentially replacing Angel Correa to start alongside Griezmann.
Real Madrid possible starting lineup:
Courtois; Carvajal, Militao, Rudiger, Nacho; Camavinga, Tchouameni, Kroos; Valverde, Benzema, Vinicius
Atletico Madrid possible starting lineup:
Oblak; Molina, Savic, Hermoso, Reinildo; Llorente, Barrios, Koke, Carrasco; Griezmann, Morata
We say: Real Madrid 2-1 Atletico Madrid
Atletico are unbeaten in their last six league matches, winning four of their last five, and they will have been preparing for this game since the clash with Athletic ended. Real Madrid, on the other hand, have had their focus elsewhere in the build-up, which could hand the visitors an advantage.
This is not the same Atletico team from previous years, though, and we are expecting Ancelotti's side to navigate their way to an important three points this weekend.