The visitors, meanwhile, are currently in sixth position, and they will be aiming to clinch their third consecutive victory in all competitions.
Match preview
Patronato have four points to their name after their opening four league matches, leaving them in 23rd place in the Primera Division.
Their league campaign began with a 1-1 home draw against Velez Sarsfield before losing 2-0 to Gimnasia in their first away match.
After picking up one point from their opening two games, Patronato bounced back in style on matchday three, picking up their first win of the Primera season.
A Facundo Cobos strike proved enough to help his side edge out Aldosivi, but they were unable to follow that win with a positive result, falling to a 3-1 away defeat in their most recent outing.
Having seen three players sent off in both of their away defeats, Patronato will be pleased to return to home surroundings, with the hosts aiming to build upon the four points they have collected from their two home games.
In contrast to their hosts, Independiente have won two of their opening four league games, helping them accumulate seven points.
Both of those league wins occurred on home turf, while their two away matches have yielded only one point, although they picked up an away cup win in their most recent encounter.
A 79th-minute strike from Juan Cazares helped Independiente squeeze past Atletico Tucuman to book their place in the last 16 of the Copa Argentina.
Following their cup victory, Independiente will now turn their attention back to league action as they bid to clinch their first away league win of the season.
They will also be aiming to continue their recent fine form in front of goal, having scored in each of their last five matches in all competitions.
Patronato Argentine Primera Division form:
Patronato form (all competitions):
Independiente Argentine Primera Division form:
Independiente form (all competitions):
Team News
After being sent off in Patronato's most recent league game, Leonel Mosevich and Diego Garcia are both suspended for Monday's contest.
Alexander Sosa came off the bench to score the equaliser in Patronato's penalty shootout win over Colon in the Copa Argentina, and the 21-year-old could be rewarded with a starting spot.
Franco Leys and Jonathan Herrera could both return to starting lineup after featuring as second half substitutes in the cup meeting with Colon.
As for the visitors, they are expected to keep changes to a minimum following their cup victory over Atletico Tucuman.
Although there could be one alteration to the lineup, with Cazares set to return to the lineup after scoring the winner in Thursday's cup game.
Meanwhile, Leandro Benegas will continue to lead the line for the visitors, having scored in three of Independiente's four league games.
Patronato possible starting lineup:
Altamirano; Lozano, Alvarez, Quintana, Cobos; Acevedo, Leys, Castro, Medina, Herrera, Sosa
Independiente possible starting lineup:
Sosa; Vigo, Barreto, Insaurralde, Rodriguez; Romero, Poblete; Fernandez, Gonzalez, Cazares; Benegas