The hosts are unbeaten in nine games across all competitions, while the German champions have won 21 of their 24 competitive matches this season.
Match preview
Having finished runners-up on two occasions, PSG are hoping that 2023 is the year where they can win the Women's Champions League trophy.
After winning three and drawing one of their six group games, the French side had to settle for second place - six points behind group winners Chelsea.
PSG can draw upon their previous success in the Champions League, having won six of their seven quarter-final ties.
Incidentally, PSG eliminated a German side at this stage of the competition last term, claiming a 4-3 aggregate victory over Bayern Munich after extra time.
Since drawing 2-2 with Montpellier in November, PSG have recorded seven consecutive home victories in all competitions, keeping five clean sheets in that period.
Wolfsburg are one of two teams who progressed through the group stage without suffering defeat, after winning four and drawing two of their six group games.
Die Wölfinnen have now reached the Women's Champions League quarter-finals in each of the last 11 seasons.
Although they have lost three of their previous six last-eight appearances, Wolfsburg managed to progress to the semi-finals last term after beating Arsenal 3-1 on aggregate.
Tommy Stroot's side began March with a surprise 2-1 home defeat to Hoffenheim, but they have bounced back to win their last two matches by a combined 9-1 scoreline.
Impressively, Wolfsburg are yet to lose an away match this season, winning 12 of their 13 competitive away games, scoring at least two goals in each of those victories.
Paris Saint-Germain Women Women's Champions League form:
L
D
W
W
W
L
Paris Saint-Germain Women form (all competitons):
Wolfsburg Women Women's Champions League form:
W
W
D
W
D
W
Wolfsburg Women form (all competitions):
Team News
PSG are unable to call upon long-term absentees Paulina Dudek, Barbora Votikova and Marie-Antoinette Katoto, while Amanda Ilestedt is expected to miss out with an ankle injury.
Sarah Bouhaddi, Li Mengwen and Oriane Jean-Francois dropped down to the bench for Saturday's cup win over Thonon Evian, but the goalkeeper may return to the starting lineup for the first leg.
Kadidiatou Diani will look to add to the 25 goals she has scored this season when she leads the line against Wolfsburg.
As for the visitors, they will be without the services of Lena Oberdorf, who sustained a knee injury in Friday's 5-0 win over Turbine Potsdam.
With Oberdorf sidelined for Wolfsburg, Jill Roord may drop back into a deeper role to partner Lena Lattwein in defensive midfield.
After being left out of Friday's lineup, Lynn Wilms, Alex Popp and Ewa Pajor will return to the starting XI on Wednesday.
Paris Saint-Germain Women possible starting lineup:
Bouhaddi; Li, Georgieva, De Almeida, Lawrence; Jean-Francois, Hamraoui, Geyoro; Martens, Baltimore, Diani
Wolfsburg Women possible starting lineup:
Frohms; Wilms, Hendrich, Janssen, Rauch; Lattwein, Roord; Huth, Popp, Jonsdottir; Pajor