The visitors only narrowly missed out on promotion during the last campaign, and both nations will be wanting to make a fast start in a group which they will expect to win.
Match preview
There have been times when Ian Baraclough has not necessarily looked the right fit for Northern Ireland, the former Under-21s boss failing to win any of his opening 11 matches in charge.
However, the second half of his 22-game stint has been much improved, the Green and White army earning five wins and posting notable draws with Switzerland and Italy.
The stalemate with the Azzurri, which ultimately cost the European champions a place at the World Cup, really caught the supporters imagination, and there is now genuine expectation that they can achieve success in this competition.
The upcoming quartet of fixtures will be tough on the legs and minds of an inexperienced squad, but victory over Greece would really set the ball rolling as they bid to earn a return to Division B.
On a negative point, Northern Ireland went down 1-0 to Hungary in the last outing, ending a three-match unbeaten streak.
As far as Greece are concerned, they are very much starting a new era with the well-travelled Gus Poyet being appointed as their new boss.
The left-field choice has delivered a mixed return so far, a 1-0 win in Romania being followed by defeat by the same scoreline in Montenegro.
For Poyet, he would have been grateful to work with his new set of players ahead of this campaign, and the Uruguayan is currently overseeing a group which includes just one outfield player who is over 30 years of age.
The biggest negative is that none of this squad have scored more than five times for their country, a record which should come as no surprise when Greece have not netted more than twice in a game since 2017.
On the flip side, Greece have not conceded more than twice in a fixture for three years, something which should provide Poyet with reason for optimism going forward.
Northern Ireland form (all competitions):
Greece form (all competitions):
Team News
Jonny Evans will return in the middle of the Northern Ireland defence, taking the place of Craig Cathcart who does not feature in the squad.
Kyle Lafferty could also deputise for the absent Josh Magennis, while Jamal Lewis may feature at left wing-back ahead of Paddy Lane.
Meanwhile, Poyet may hand an immediate Greece debut to George Baldock as a result of Lefteris Lyratzis not being in the squad.
Giorgos Masouras could get the nod in a wide position in the absence of Dimitris Pelkas, but Vangelis Pavlidis should keep his place in attack.
Having not gotten on the pitch in the Champions League final, Liverpool left-back Kostas Tsimikas is in line to play.
Northern Ireland possible starting lineup:
Peacock-Farrell; Brown, Evans, Ballard; McNair, Davis, McCann, Lewis; Whyte, Lafferty, McGinn
Greece possible starting lineup:
Vlachodimos; Baldock, Mavropanos, Chatzidiakos, Tsimikas; Bouchalakis, Siopis, Bakasetas; Douvikas, Pavlidis, Masouras
We say: Northern Ireland 1-1 Greece
With both nations seemingly on the up, this should be a competitive encounter. Northern Ireland will start as the marginal favourites, but we are expecting the visitors to strike in the final third at some stage, earning a draw that will be deemed more than satisfactory by their supporters.