The Bees, meanwhile, will be seeking to avoid a third successive top-flight game without a win.
Match preview
After enduring a difficult run of six Premier League games without a win, Newcastle secured maximum points in emphatic fashion when they beat Fulham 4-1 away from home last weekend.
The dismissal of Fulham's Nathaniel Chalobah just eight minutes into the contest unsurprisingly benefitted the Magpies, and a brace from Miguel Almiron along with goals from Callum Wilson and Sean Longstaff put them four-goal in front before the hour mark. Bobby Decordova-Reid then netted a consolation strike late on to prevent Nick Pope from keeping a fourth clean sheet this term.
Eddie Howe expressed a sense of relief at full time after his side claimed just their second league win of the season from eight games, but nevertheless they have climbed up to a respectable seventh place in the table, just three points off the top four and only one point behind sixth-placed Manchester United, who the Magpies will face next weekend.
Newcastle have turned St James' Park into somewhat of a fortress in recent months, as they have lost only one of their last 14 league matches on home soil, although their last three have finished as a draw.
The Magpies also have an impressive record against Saturday's opponents Brentford, as they are unbeaten in their last six league meetings against them, winning five times and drawing one - their last home encounter was in fact an entertaining 3-3 draw at St James' Park in November last year.
After scoring in each of their opening six Premier League matches, netting 15 times in the process, Brentford have since drawn a blank in front of goal in their last two fixtures against Arsenal and Bournemouth.
A 3-0 home defeat to the Gunners before the international break was followed by a frustrating goalless draw away against the Cherries last weekend.
Thomas Frank's side are clinging on to a place in the top half of the table, sitting in 10th spot and level on points in between Merseyside rivals Liverpool and Everton, while there are four points separating the Bees from both the top four and the relegation zone.
Brentford ended a run of 19 consecutive away games in the league without a clean sheet when they played out a goalless draw against Bournemouth last time out, and they will now be looking to keep back-to-back top-flight shutouts on the road for the first time since a run of three away clean sheet between December 1937 and January 1938.
However, the Bees have struggled to keep the ball out of the net when facing Newcastle in the North East, as they have conceded 11 times in their last three meetings at St James' Park.
Newcastle United Premier League form:
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Newcastle United form (all competitions):
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Brentford Premier League form:
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Brentford form (all competitions):
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Team News
Newcastle's injury-prone striker Callum Wilson played for just over an hour last weekend and is expected to start again up front, as both Alexander Isak and Chris Wood remain sidelined with respective muscle and rib injuries.
Jonjo Shelvey, Emil Krafth and Karl Darlow are also ruled out with long-term issues, while Allan Saint-Maximin is doubtful with a thigh problem and will be assessed ahead of kickoff.
Bruno Guimaraes, Joe Willock and Sean Longstaff all performed well alongside each other in centre-midfield last week, and the trio are expected to retain their places in the first XI, while Jacob Murphy will face competition from Ryan Fraser to start in the front three.
As for Brentford, Pontus Jansson hobbled off midway through the second half against Bournemouth after sustaining a hamstring injury, and the Swedish centre-back will miss the trip to St James' Park.
Christian Norgaard is also ruled out with an Achilles problem, while Ethan Pinnock (knee) and Keane Lewis-Potter (knock) are both doubtful.
With Aaron Hickey expected to return to the first XI at right-back, Kristopher Ajer could move over the centre-back in Jansson's absence, while Josh Dasilva may return to centre-midfield at the expense of Shandon Baptiste.
Ivan Toney and Bryan Mbeumo are regular starters under Frank and are set to continue in attack, with either Mikkel Damsgaard or Yoane Wissa joining them in the front three.
Newcastle United possible starting lineup:
Pope; Trippier, Schar, Botman, Burn; Willock, Guimaraes, S. Longstaff; Almiron, Wilson, Fraser
Brentford possible starting lineup:
Raya; Hickey, Ajer, Mee, Henry; Jensen, Janelt, Dasilva; Mbeumo, Toney, Wissa
We say: Newcastle United 2-1 Brentford
The last five meetings between these two sides at St James' Park have seen a total of 24 goals scored at an average of 4.8 per match, and there could plenty more goalmouth action in the North East this weekend.