While Inter snuck past Hellas Verona to retain their advantage over old foes Juventus, mid-table Monza moved closer to the top half of the standings with their first win in four games.
Match preview
Claiming the crown of 'Campioni d'Inverno' (winter champions), Inter won their first fixture of the new year at San Siro last time out, but it took a stoppage-time strike from Davide Frattesi to see off relegation-threatened Verona.
It seemed the game was set for a 1-1 draw after captain Lautaro Martinez saw his early goal levelled in the 74th minute, but Frattesi's intervention ensured his side would sit top of the table after 19 league matches.
Not only that, but a total of 48 points is the Nerazzurri's best tally at this stage of any campaign since 2006-07, and an impressive goal difference of +35 sets a new club record.
On 10 of 17 previous occasions Inter have led Serie A at the season's midpoint they have ultimately gone on to secure the Scudetto, and they appear to be locked in a two-horse race with Juventus to claim the title this time around.
Having stumbled slightly by drawing with Genoa following four wins on the spin, Simone Inzaghi's side quickly bounced back by edging out Verona, and they must now keep momentum building against Monza.
Inter's short trip to their regional rivals will be followed by a far longer journey to Saudi Arabia for the Supercoppa Italiana, and then an away game against Fiorentina precedes a potentially decisive Derby d'Italia clash with Juve next month.
After avoiding defeat in both meetings with Inter last season, including a memorable 1-0 win at San Siro, Monza lost this term's reverse fixture 2-0, with a brace from Martinez consigning them to defeat on the opening matchday.
The Biancorossi have also won none of five previous home matches against their Lombardy neighbours in all competitions, so they will now have to break new ground if they are to take maximum points for the second time in 2024.
Although Raffaele Palladino's men almost frittered away a three-goal lead at Frosinone last weekend, they still left Stadio Benito Stirpe with a 3-2 win that left them 11th in the table - much closer to the top six than Serie A's drop zone.
However, Monza have picked up just four of their 25 points against teams inside the top half of the table, and ahead of Inter's visit they have also seen their previously unbeaten home record spoiled by a couple of recent defeats.
Having lost two of their last three home matches - as many as in the previous 13 - Palladino and co will hope to turn that trend around sooner rather than later. Doing so on Saturday night, though, could prove a tough task.
Monza Serie A form:
L
W
L
L
D
W
Inter Milan Serie A form:
W
W
W
W
D
W
Inter Milan form (all competitions):
D
W
L
W
D
W
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Team News
Aside from Juan Cuadrado's absence following Achilles surgery, Inter have no injury concerns this weekend, with Simone Inzaghi's squad also set to be bolstered by new arrival Tajon Buchanan.
While the Canadian wing-back should start on the bench, captain Lautaro Martinez - who is reportedly on the verge of signing a new contract - will start alongside Marcus Thuram in attack.
'El Toro' has been involved in 18 Serie A goals this term - 16 of his own and two assists - so bagging another brace against Monza would see him reach at least 20 goal involvements in each of the last four seasons. Across Europe's top five leagues, Mohamed Salah, Kylian Mbappe and Harry Kane are the only other men to have done so.
Meanwhile, Monza must make do without goalkeeper Michele Di Gregorio for the next few weeks, after the Inter primavera graduate suffered a thigh injury in Frosinone; inexperienced reserve Alessandro Sorrentino deputises for the highly-rated shot-stopper.
Another product of their visitors' youth system, Valentin Carboni - who scored again last week - is set to feature in the Biancorossi's forward line. Andrea Colpani and Dany Mota are also fighting it out with AC Milan-owned Lorenzo Colombo for selection.
Furthermore, ex-Inter defenders Luca Caldirola and Danilo D'Ambrosio will line up in the back three, while Roberto Gagliardini should start in central midfield.
Monza possible starting lineup:
Sorrentino; D'Ambrosio, Mari, Caldirola; Birindelli, Gagliardini, Pessina, Ciurria; Colpani, V. Carboni; Mota
Inter Milan possible starting lineup:
Sommer; Pavard, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Martinez