The Reds Devils head into the weekend in fourth spot, while the Robins are propping up the table with just six points to their name.
Match preview
Manchester United have experienced a frustrating WSL campaign, having won seven, drawn four and lost four of their 15 league matches.
In their most recent league outing, the Red Devils conceded an 85th-minute equaliser to draw 1-1 with West Ham United after leading for the majority of the contest.
While they have experienced inconsistency in the league, Man United still have the chance to win silverware this season after they secured their spot in the FA Cup final with a commanding 4-0 win over Brighton & Hove Albion last weekend.
Millie Turner and Nikita Parris grabbed a goal apiece in the opening 20 minutes, before Lucia Garcia and Lisa Naalsund added to a third and a fourth to set up a semi-final clash with current holders Chelsea.
Marc Skinner's side will now turn their focus back to league action, with Sunday's hosts hoping to record a fourth consecutive home win in all competitions.
Having won just one of their 15 league matches, Bristol City have their work cut out if they are to avoid an immediate return to the Championship.
The Robins are rooted to the bottom of the table and six points adrift from safety following their recent heavy 7-3 defeat to Brighton.
Bristol City fought back from 4-1 down to reduce the deficit to just one goal thanks to efforts from Brooke Aspin and Amalie Thestrup.
However, Brighton produced a late burst to net three more goals and condemn the Robins to their fifth defeat in six league matches.
As a result of the disappointing loss, Lauren Smith's side have now shipped 45 goals in the WSL this season, leaving them with the worst defensive record in the top flight and highlighting one of the major factors behind their lowly league position.
Manchester United Women Women's Super League form:
L
L
W
W
L
D
Manchester United Women form (all competitions):
Bristol City Women Women's Super League form:
L
L
L
D
L
L
Bristol City Women form (all competitions):
Team News
Man United remain without the services of Gabby George, Emma Watson, Evie Rabjohn, Jess Simpson and Hinata Miyazawa.
Leah Galton will be absent for a second consecutive game after she missed the FA Cup win over Brighton due to a thigh strain.
Brazil international Geyse has returned from the Gold Cup in the USA and is expected to feature in the matchday squad.
As for the Robins, they are unable to call upon Satara Murray and Chloe Mustaki, while Carrie Jones is a doubt after picking up a knock in training.
Abi Harrison is closing in on a return from injury and is set to travel with the squad for Sunday's clash at Leigh Sports Village.
Thestrup will be looking to continue her fine run of form after finding the net in each of Bristol City's last four competitive matches.
Manchester United Women possible starting lineup:
Earps; Riviere, Le Tissier, Turner, Blundell; Zelem, Naalsund; Garcia, Toone, Malard; Parris
Bristol City Women possible starting lineup:
Clark; Morgan, Aspin, Connolly, Struck, Powell; Evans, Syme, Rodgers, Hayles; Terland