Rob Edwards's charges blew a 3-0 lead in an astounding 4-3 loss to Bournemouth in midweek, while Nuno Espirito Santo's side are also reeling from a one-goal defeat to Brighton & Hove Albion.
Match preview
Three months on from Tom Lockyer's traumatic cardiac arrest on the field - leading to the postponement of Bournemouth's clash with Luton Town at the Vitality Stadium - the two clubs renewed acquaintances on Wednesday evening in front of the recovering Hatters captain, whose presence was warmly received by both sets of fans.
Lockyer witnessed a scarcely believable first-half performance from his side, who went into the break three goals to the good thanks to Ross Barkley, Chiedozie Ogbene and Tahith Chong, but Rob Edwards's men would subsequently become the victims of a type of Premier League comeback not seen in 20 years.
Dominic Solanke's strike, Ilya Zabarnyi's header and Antoine Semenyo's brace saw Bournemouth become just the fifth team in the history of the competition to win a game after falling three goals down, and as much as the Cherries' incredible turnaround warranted the plaudits, Luton's catastrophic collapse was as much to blame.
Defeat at the Vitality crucially meant that the Hatters wasted their opportunity to climb out of the relegation zone with their game in hand, but with a three-point gap to make up to upcoming foes Forest, they have been gifted a second bite at the safety cherry and will rise to 17th with a win by any margin this weekend.
However, after ending January with a trio of successive victories, Luton are now winless in eight straight fixtures - conceding at least three goals in six of those contests - although their 16-game scoring run in the top flight is the best for a newly-promoted side since the Newcastle United crop of 1993-94 registered in 20 matches in a row.
While putting the ball in the back of the net is seldom an issue for Edwards's troops, Nottingham Forest failed to fire for the second top-flight game running - and third in all tournaments - at the Amex Stadium, where there were shades of their crushing and controversial 1-0 loss to Liverpool in an identical defeat.
Andrew Omobamidele's own goal settled the match in the Seagulls' favour, although Santo was left seething after Jakub Moder escaped a red card for an ugly tackle on Neco Williams, and the ex-Tottenham Hotspur boss felt that his side's performance warranted more than a defeat.
However, the Tricky Trees once again found it tricky to find a killer instinct in front of goal, and as well as running the risk of going three Premier League games without scoring for the first time since 1999, Santo's side will end the weekend in the relegation zone if they lose at Kenilworth Road.
Forest's declining form can be partially attributed to an anxious wait over a potential points deduction, but the visitors have done themselves no favours against newly-promoted sides either, only winning one of their last 18 such games in the Premier League and drawing eight of their most recent nine on the road.
Furthermore, not since October 7 have the Garibaldi kept a clean sheet away from home in the top flight - conceding in their last nine on rival turf - and a 2-2 draw with Luton at the City Ground in October extended their winless run against the Hatters to five matches.
Luton Town Premier League form:
L
L
L
L
D
L
Luton Town form (all competitions):
L
L
L
L
D
L
Nottingham Forest Premier League form:
D
L
W
L
L
L
Nottingham Forest form (all competitions):
L
W
L
L
L
L
Team News
Amid all the goalmouth chaos in the second half of Wednesday's seven-goal spectacular, deadlock-breaker Chong came off with an injury of unspecified severity, so either Andros Townsend or Cauley Woodrow should gear up to start in his place this weekend.
Chong might be one of 11 absentees for the decimated Hatters, who are guaranteed to be missing Joe Johnson (glandular fever), Gabriel Osho (knee), Mads Andersen (calf), Jacob Brown (knee), Albert Sambi Lokonga (thigh), Elijah Adebayo (thigh), Dan Potts (thigh), Marvelous Nakamba (knee), Amari'i Bell (thigh) and Lockyer.
With so few senior options for change, most of Edwards's starters from Wednesday night should reprise their roles at Kenilworth Road, but Pelly Ruddock Mpanzu might be preferred as a makeshift defender to Daiki Hashioka, who was given a rough ride by Semenyo in midweek.
In contrast, Nottingham Forest only have a quartet of stricken players taking up beds in the infirmary, two of whom - Giovanni Reyna and Ola Aina - might force their way back into contention for the weekend.
However, Gonzalo Montiel (muscle) and Arsenal loanee Nuno Tavares (unspecified) are not expected to make the cut, but Santo should not shy away from making a handful of alterations in the final third.
All of Taiwo Awoniyi, Anthony Elanga and Callum Hudson-Odoi were benched for the trip to the Amex, but at least two of the trio should now be in consideration to take the places of Chris Wood and Divock Origi after another toothless attacking display.
Luton Town possible starting lineup:
Kaminski; Mpanzu, Mengi, Burke; Kabore, Barkley, Clark, Doughty; Woodrow, Ogbene; Morris
Nottingham Forest possible starting lineup:
Sels; Williams, Omobamidele, Murillo, Toffolo; Dominguez, Yates; Elanga, Gibbs-White, Hudson-Odoi; Awoniyi
We say: Luton Town 2-2 Nottingham Forest
As poor as Forest have been in the attacking third recently, the fresh legs of Awoniyi, Elanga and Hudson-Odoi should be backed to trouble a leaky Luton backline, especially one working with minimal rest after Wednesday's extraordinary affair.