While both teams have seven points to their name, Man City sit top of the Women's Super League table due to their superior goal difference.
Match preview
After battling relegation in the last two seasons, Leicester have already made significant steps to avoiding another survival fight this term.
The Foxes began the campaign with league victories over Bristol City and Everton, before they claimed a narrow 2-1 win against Liverpool in their first group game of the League Cup.
They were unable to continue their winning run in their most recent outing against Manchester United, but they would have been content with a 1-1 draw against last season's runners-up.
As one of three teams yet to lose in the WSL this season, Leicester are currently sitting level on points with Saturday's opponents and the reigning champions Chelsea.
Having lost all of their previous four WSL meetings with Man City, the Foxes know they will have to be at their best if they are to extend their unbeaten start to the season.
After missing out on the top three last season, Man City will have hopes of mounting a serious title challenge this term.
They began the campaign with a 2-0 win over West Ham United, before they conceded a late equaliser to draw 1-1 with Chelsea in a game where they were reduced to nine players.
After returning to winning ways in their League Cup meeting with Everton, the Citizens produced a dominant display to thrash newly-promoted Bristol City 5-0 last weekend.
All five goals for Gareth Taylor's side arrived in the first half, with Jill Roord and Bunny Shaw netting braces alongside a Laia Aleixandri effort.
That result extended their unbeaten home run to 22 WSL matches, but they will now head on their travels, where they will attempt to claim a third consecutive away victory in all competitions.
Leicester Women Women's Super League form:
L
L
W
W
W
D
Manchester City Women Women's Super League form:
L
L
W
W
D
W
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Team News
Leicester boss Willie Kirk has confirmed that he has no fresh injury concerns, but he is still unable to call upon Australian forward Remy Siemsen.
Jutta Rantala, who featured as a half-time substitute last weekend, is in contention to start Saturday's home clash with the Citizens.
Lena Petermann will continue to lead the line for the hosts, and she will be looking to add to her two-goal tally for the season.
As for the visitors, defender Demi Stokes remains unavailable for the weekend, but there is hope that she will return to action after the international break.
After missing the win over Bristol City with a shoulder issue, Lauren Hemp has made a full recovery and is set to feature in the starting lineup.
The England international will feature in a front three, where she is expected to be joined by Chloe Kelly and Shaw.
Leicester Women possible starting lineup:
Leitzig; Bott, Howard, Green, Nevin; Goodwin, Whelan, Tierney, Cayman, O'Brien; Petermann
Manchester City Women possible starting lineup:
Keating; Morgan, Kennedy, Greenwood, Aleixandri; Angeldal, Hasegawa, Roord; Hemp, Kelly, Shaw