While the Saints are continuing with interim boss Ruben Selles for the time being, the Whites are set to have newly-appointed head coach Javi Gracia in the dugout for the first time, subject to obtaining a work permit.
Match preview
Fifteen days after sacking Jesse Marsch, Leeds confirmed the appointment of Javi Gracia as their new head coach on Tuesday, bringing an end to Michael Skubala's temporary three-game spell in charge.
The 52-year-old, who has penned a "flexible contract" with the West Yorkshire side, is tasked with steering his new team away from the relegation zone, as they currently sit 19th in the table and two points adrift of safety following a torrid 10-game winless league run, including a 1-0 loss at Everton last weekend.
Leeds will hope Gracia can use his previous Premier League experience to steer the club to safety after helping Watford avoid the drop in the second half of the 2017-18 campaign, before guiding them to their highest-ever top-flight finish of 11th place the following season, as well as leading them to the FA Cup final.
Gracia is yet to lead team training at Leeds, but the Whites are hopeful the Spaniard will receive his work permit in time to take charge of Saturday's clash with Southampton, coincidently the same opponent Gracia faced in his first game in charge of Watford, albeit losing 1-0 in the FA Cup.
Leeds have struggled to please their home supporters in recent weeks as they have only won one of their last 10 Premier League matches at Elland Road, failing to score in their last two against Brentford (0-0) and Manchester United (0-2).
However, the Whites will be optimistic of claiming a positive result on Saturday as they have only lost one of their last 14 meetings against Southampton and are unbeaten in their last eight since a 1-0 home defeat back in February 1998.
Following the dismissal of Nathan Jones, interim boss Ruben Selles boosted his hopes of leading Southampton on a permanent basis after steering the Saints to an impressive 1-0 away victory over Chelsea last weekend.
A trademark James Ward-Prowse free kick was enough to separate the two sides and end Southampton's three-game losing run, although that victory was not enough to move them off the foot of the table and they are still three points adrift from safety.
Nevertheless, Selles has restored belief in his Saints side, who will be seeking to claim their third Premier League away win in four matches when they travel to Elland Road this weekend.
Indeed, Southampton have fared much better on the road so far this season, accumulating 12 of their 18 points away from home which is more than nine other top-flight teams including Liverpool (11).
Southampton came from two goals down to rescue a 2-2 draw at home against Leeds back in August, courtesy of goals from Joe Aribo and Kyle Walker-Peters in the final 20 minutes, and that fighting spirit will be required if they wish to go one better and claim all three points on Saturday, with a win potentially enough to help them climb out of the drop zone on goal difference if other results go their way.
Leeds United Premier League form:
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Leeds United form (all competitions):
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Southampton Premier League form:
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Southampton form (all competitions):
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Team News
Leeds trio Rodrigo (ankle), Stuart Dallas (leg) and Adam Forshaw (groin) are still recovering from long-term injuries, although the former is hoping to return at some stage next month.
Maximilian Wober came off at half time against Everton with a suspected dislocated shoulder and is a doubt for Saturday's clash along with Luis Sinisterra (thigh), Pascal Struijk (concussion), Marc Roca (knock) and Archie Gray (ankle).
In the potential absence of Wober, captain Liam Cooper could be recalled to partner Robin Koch at centre-back, although he may not be able to play the full 90 minutes having just returned from injury, so Luke Ayling could feature in the middle at some stage in the game.
It remains to be seen how Gracia will line up his side for Saturday, but Patrick Bamford - who has scored three Premier League goals in his last four meetings with Southampton - is set to lead the line, while Brendan Aaronson and Georginio Rutter will be pushing to be involved in the first team after both attackers played for the club's Under-21s on Monday.
As for Southampton, Che Adams and Mohammed Salisu both missed the win at Chelsea after picking up minor injuries in training and they remain doubtful for Saturday, while Valentino Livramento (ACL) and Juan Larios (hamstring) are still out with long-term problems.
Walker-Peters watched on as an unused substitute last weekend after recovering from a hamstring strain, and the right-back will be hoping to force his way back into the first XI on Saturday ahead of Ainsley Maitland-Niles.
Ward-Prowse is set to make his 329th Premier League appearance, equalling the club record set by Jason Dodd, while one of Romeo Lavia, Carlos Alvarez or Ibrahima Diallo will likely join the Saints skipper in centre-midfield.
January signings Paul Onuachu and Kamaldeen Sulemana could start their third successive game in attack, although they face competition from Sekou Mara, Adam Armstrong and Theo Walcott.
Leeds United possible starting lineup:
Meslier; Kristensen, Koch, Cooper, Firpo; Adams, McKennie; Summerville, Aaronson, Gnonto; Bamford
Southampton possible starting lineup:
Bazunu; Maitland-Niles, Bednarek, Bella-Kotchap, Perraud; S. Armstrong, Ward-Prowse, Lavia, Elyounoussi; Sulemana, Onuachu
We say: Leeds United 2-2 Southampton
The Elland Road faithful are sure to create a hostile atmosphere for Southampton while providing new boss Gracia with all the encouragement he needs to get off to a flying start in the Leeds dugout.