After a difficult week, in which they crashed out of continental competition and lost away to Athletico Paranaense, the hosts will hope their visitors' confidence has been dented by a midweek defeat that ended a four-match unbeaten run.
Match preview
Having claimed just nine points from their seven away games so far this season following last week's loss in Parana, Internacional return to their Estadio Beira-Rio headquarters this weekend, aiming to improve an even weaker home record.
In fact, the struggling giants have earned only five points as hosts this term, with three of those coming from a narrow 1-0 win over ten-man Juventude last time they stepped out on home turf.
Since that rare victory for Diego Aguirre's side, who continue to toil in the bottom half of the table, Inter have been eliminated from the Copa Libertadores on penalties - a heartbreaking conclusion to their last-16 tie with Olimpia - and then lost again in the league.
Unable to break the deadlock throughout both legs of their Copa clash with the Paraguayan side - despite having beaten them 6-1 during the group stage - Aguirre has seen his team register just two goals from their six most recent games and confidence in the final third is certainly at a low ebb.
Formerly in charge of the club for a brief spell back in 2015, the Uruguayan coach recently returned after the sacking of Miguel Angel Ramirez, and clearly has his work cut out if Inter are to avoid a lengthy basement battle and move into the upper echelons of the table.
Also out of the Copa do Brasil, all focus will now be on salvaging their league season - starting with the hunt for back-to-back home wins on Sunday.
After finally winning consecutive games to edge themselves up the Serie A standings - their only two triumphs of this campaign - Cuiaba came back down to earth last time out, as they suffered a 2-1 home loss to Corinthians.
Two goals down before the break, the Dourado were unable to fight their way back into the match before Anderson Conceicao's late dismissal put the seal on a disappointing defeat.
Cuiaba's ambitions are realistic, however, as they were only promoted to Serie B in 2019, before gaining a place in the top tier of the Campeonato Brasileiro for the first time this season.
The only team from the central state of Mato Grosso to reach the elite level since 1986, they have endured a steep learning curve so far, but are certainly in the mix for survival - currently sitting 15th in a tightly packed bottom half of the table.
Former Brazil and Bayern Munich full-back Jorginho, who lifted the World Cup at USA '94, has had an itinerant coaching career to date - taking charge of 14 clubs during the past decade - and took his place in the Cuiaba hot-seat recently, after interim boss Luiz Fernando Iubel stepped in following Alberto Valentim's departure in May.
Even if his only major managerial success came at Kashima Antlers over eight years ago, Jorginho's experience at the highest level as a player can surely help a modest playing squad continue their adaptation to the big time, as he takes them to one of Brazil's established giants this weekend.
Internacional Brasileiro form:
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Cuiaba Brasileiro form:
Team News
Internacional's problems in goal show no signs of abating, with midfielder Edenilson's successful spot-kicks accounting for three out of their four goals since the end of June.
The former Udinese man will start in an advanced role on Sunday, most probably in support of a lone striker, whose identity remains a mystery, as struggling striker Yuri Alberto and alternative attacking option Thiago Galhardo are both suspended due to accumulated bookings.
Experienced forwards Paolo Guerrero and Taison also remain sidelined with knee and ankle injuries respectively, while defender Ze Gabriel is ruled out too.
Cuiaba, meanwhile, must reshuffle in defence, as centre-back Anderson Conceicao must serve a suspension for his stoppage-time red card last time out. Both Walter and Murilo Rangel are doubtful due to injuries.
Head coach Jorginho has opted for a settled defensive setup since taking charge, with Paulao likely to step back into his favoured back four in Porto Alegre.
Internacional possible starting lineup:
Daniel; Heitor, Mendez, Cuesta, Moises; Cardoso, Dourado; Vidal, Edenilson, Patrick; Palacios
Cuiaba possible starting lineup:
Walter; Lucas, Marllon, Paulao, Uendel; Danilo, Junior, Pepe, Gava; Elton, Clayson
We say: Internacional 1-1 Cuiaba
Already lacking firepower up front, Internacional must deal with a raft of injuries and suspensions among their attacking department, so are unlikely to spring into life this week - even against a Cuiaba side which leaks plenty of goals.
Inter's malaise is set to continue into the new month, then, while their visitors will happily snap up a precious point in their quest for a second shot at Serie A next term.