While the hosts occupy 22nd position in the Argentine Primera Division table, Belgrano currently reside in seventh place after collecting 34 points from 21 matches.
Match preview
Instituto are competing in their first top-flight campaign since 2005-06 after winning promotion from the second tier last term.
They have managed to scrape together 22 points, but they are currently experiencing a poor spell of form, having failed to win any of their last five league games.
In their most recent outing, they made the trip to Estadio Mas Monumental to face River Plate, and their hopes of claiming a positive result received a boost when Santiago Rodriguez opened the scoring in the first minute, but they were unable to hold out until half time.
Their task became all the more difficult when Leonel Mosevich was sent off, and River Plate made full use of the numerical advantage, adding two more goals to their tally to condemn Instituto to a six consecutive away defeat.
Having lost just one of their last six league games at the Estadio Presidente Peron, Diego Dabove's side will be looking forward to returning to home surroundings on Sunday.
Belgrano, meanwhile, will be looking to claim a second straight victory after claiming a 3-1 home victory over Banfield last weekend.
Pablo Vegetti saw his opener cancelled out by an Alejandro Rebola own goal, before the Belgrano forward restored his side's advantage with his second goal of the game.
Franco Jara found the net in the 76th minute to round off the scoring, but he was subsequently shown a second yellow card for removing his shirt during his celebration.
The win extended Belgrano's unbeaten home run to eight league games, but they have struggled to transfer that form onto their travels in recent weeks.
Sunday's visitors have lost their last four away matches in the Primera Division without scoring, and as a result, they will be aiming to clinch their first away league victory since April 16.
Instituto Argentine Primera Division form:
W
L
D
L
D
L
Belgrano Argentine Primera Division form:
L
D
L
W
L
W
Team News
The hosts are unable to call upon the services of Lucas Albertengo, who is currently sidelined with an injury issue.
After being sent off in the defeat to River Plate for two bookable offences, Mosevich will serve a one-match suspension.
Adrian Martinez has scored seven goals in his 20 league appearances this season, and he will attempt to add to his tally when he leads the line alongside Rodriguez.
As for the visitors, they are still expected to be without Francisco Oliver and Ignacio Tapia due to injury problems.
Jara will miss Sunday's contest through suspension after being sent off in the 3-1 victory over Banfield.
With 13 league goals to his name, Vegetti currently tops the scoring charts in the Primera Division, and he will attempt to continue his fine form against Instituto.
Instituto possible starting lineup:
Roffo; Franco, Parnisiari, Alarcon, Corda; Graciani, Linares, Lodico, Watson; Rodriguez, Martinez
Belgrano possible starting lineup:
Losada; Barinaga, Rebola, Meriano, Ibacache; Pereira, Longo; Sanchez, Zapelli, Hesar; Vegetti