Meanwhile, Rosario make the journey looking to secure back to back wins for the first time this season after ending a three-game losing streak last time out.
Match preview
Independiente came away empty-handed from a 1-0 defeat against city rivals Racing Club in Saturday's clash at the Estadio Juan Domingo Peron.
Eduardo Dominguez's men conceded a ninth-minute opener to Gabriel Hauche and that was enough to decide what was a keenly-contested affair.
Having managed to amass just seven points from as many games this term, Los Diablos Rojos have now slipped down to 22nd in the league table, just three points off the bottom.
Awaiting them next is the challenge of an opposing outfit who have only come out on top in just one of the last six meetings between the sides.
However, that solitary win came in the most recent encounter back in April when Saturday's went down without a whimper in a resounding 3-0 loss.
Rosario Central claimed a first win in four outings as they saw off the threat of Sarmiento Junin in a narrow 1-0 victory at the Estadio Gigante de Arroyito.
Carlos Tevez's men had a man advantage since the 32nd minute but it took an extra three-quarters of an hour before the deadlock was finally broken by Facundo Buonanotte.
As a result, El Canalla have moved up to 23rd in the standings, level on points with this weekend's opponents ahead of the contest in Avellaneda.
One of two teams still yet to record a single point away from home so far, Saturday's visitors will be keen to end a run of seven straight losses on their travels.
Independiente Argentine Primera Division form:
Independiente form (all competitions):
Rosario Central Argentine Primera Division form:
Team News
Independiente are set to be without their topscorer Leandro Benegas who missed the defeat to Racing Club with a hamstring problem.
The away side will also have to make do with the absence of Damian Batallini after he was forced off with a first-half injury in the aforementioned game.
Marcelo Benitez was absent from Rosario Central's victory over Sarmiento last time out, making the Argentine a huge doubt for this weekend's clash.
Twenty-one-year-old Luca Martinez remains without an appearance since February and is still a long way off making his return to action.
The Argentine duo of Francesco Lo Celso and Jorge Broun also miss out for the away side as they continue to nurse long-term knee injuries.
Independiente possible starting lineup:
Sosa; Rodriguez, Laso, Barreto, Vigo; Romero, Marcone; Fernandez, Gonzalez, Hachen; Ferreyra
Rosario Central possible starting lineup:
Servio; Cortez, Baez, Almada, Blanco; Buonanotte, Montoya, Malcorra, Infantino; Frias, Candia