Meanwhile, the away side make the trip to Istanbul aiming to arrest a slump in form which has seen them lose five games in a row across all competitions.
Match preview
Galatasaray saw off the threat of Giresunspor in a comprehensive 4-0 victory when the sides faced off at the Cotanak Stadyumu on Saturday evening.
Okan Buruk's men opened the scoring on the stroke of half time through Dries Mertens after which strikes from Leo Dubois, Milot Rashica and Yunus Akgun put the result beyond doubt.
Consequently, Gala have now picked up maximum points from each of their last 10 matches and sit top of the Turkish Super Lig table, four points clear of city rivals Fenerbahce.
Next up is the challenge of an opposing outfit who have been beaten in each of the previous four editions of this fixture by a combined score of 10-2.
Having failed to come out on top in just two of their nine league games on home turf this term, Wednesday's hosts will be confident of getting the job done in front of their fans once again.
Umraniyespor fell to an agonising 3-2 defeat against Antalyaspor in Saturday's thrilling encounter between the teams at the Antalya Stadyumu.
Recep Ucar's men took the lead through Umut Nayir but goals from Sam Larsson and Guray Vural turned the game on its head after which Onur Ayik struck to restore parity, only for Fredy to decide the tie with a late winner.
With 21 points amassed from 19 outings so far, the Star of the South are 13th in the standings, just two points clear of relegation danger, albeit with a game in hand.
Off the back of a first away defeat in six outings last time out, Wednesday's visitors set out to avoid back to back losses on the road for the first time since October.
Galatasaray Turkish Super Lig form:
W
W
W
W
W
W
Umraniyespor Turkish Super Lig form:
W
D
W
L
L
L
Team News
Since returning to action, Galatasaray's Dries Mertens has found the back of the net in two of his three appearances and he is certainly one to look out for.
Twenty-two-year-old Mathias Ross remains ruled out for the hosts through a long-term knee injury, while Yusuf Demir continues to nurse a muscle problem.
Leading goalscorer Bafetimbi Gomis has had to make do with a place on the bench in each of the last two games but he could be recalled to the lineup for this one.
Onur Atasayar will be pushing for a return to the starting XI here after the defender missed Umraniyespor's last outing through suspension.
With goals in three matches on the bounce leading up to Wednesday's contest, Umut Nayir will be looking to come up with the goods once again.
Galatasaray possible starting lineup:
Muslera; Dubois, Bayram, Nelsson, Boey; Oliveira, Torreira; Yilmaz, Mertens, Akturkoglu; Gomis
Umraniyespor possible starting lineup:
Ozdemir; Lenjani, Epureanu, Sackey, Popov; Avounou, Kayra, Gurbulak; Bettaieb, Nayir, Geraldo