The hosts are looking to avoid a third defeat on the bounce, while the away side go in search of a fourth consecutive win to continue their fine start to the new campaign.
Match preview
Ajax claimed an emphatic 9-0 victory over newly-promoted Cambuur at the Johan Cruyff ArenA on Saturday to maintain their perfect record on home turf this term.
David Neres was the star of the show as he grabbed two goals in a game where Jurrien Timber, Steven Berghuis, Noussair Mazraoui, Dusan Tadic, Mohamed Daramy, Sebastien Haller and Danilo all got on the score sheet.
Having dropped just two points so far, Erik ten Hag's men have now risen to the top of the table, a point above last season's runners-up PSV Eindhoven.
Awaiting them next is a visit to an opposing side who they have beaten in each of the previous five meetings involving the teams dating back to 2018.
With 22 goals scored already across the first five games, Tuesday's hosts will be poised to put on another impressive display in attack.
Fortuna Sittard were left empty-handed for the second game in a row away from home following a 1-0 loss against Heerenveen on Saturday.
The deadlock was broken five minutes into the contest by Henk Veerman, and that was enough to condemn Sjors Ultee's men to defeat at the Abe Lenstra Stadion.
The Forunezen have now picked up just four points from as many outings so far and are just above the drop zone on goal difference ahead of a daunting fixture versus the reigning champions.
However, Tuesday's hosts are yet to be beaten on their own patch this term which should serve as a confidence boost heading into the clash.
Fortuna Sittard Eredivisie form:
Fortuna Sittard form (all competitions):
Ajax Eredivisie form:
Ajax form (all competitions):
Team News
Fortuna's Lisandro Semedo will miss the trip to Amsterdam due to an ankle injury which has seen him play no part in any of his side's outings this season.
The hosts will also take to the pitch without the services of 24-year-old forward Arianit Ferati who is currently battling with an illness.
Davy Klaassen and Maarten Stekelenburg are ruled out of the game due to groin injuries, while Sean Klaiber remains out of action with a knee problem.
Mohammed Kudus was named on the bench last time out, but the Ghanaian may not be rushed back into the thick of it as he is just recuperating from an ankle problem.
Danilo opened his account for the senior team less than five minutes after coming on as a substitute which could see him handed a run of games.
Fortuna Sittard possible starting lineup:
Van Osch; Cox, Janssen, Angha, Tirpan; Rienstra, Tekie, Duarte; Seuntjens, Sambou, Hansson
Ajax possible starting lineup:
Pasveer; Mazraoui, Timber, Martinez, Blind; Alvarez, Gravenberch, Berghuis; Antony, Tadic, Haller
We say: Fortuna Sittard 0-4 Ajax
The visitors look unstoppable at the moment as they are performing superbly at both ends of the pitch. We fancy them to romp to another comfortable triumph, scoring plenty of goals en route.